Literature DB >> 2516847

Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

H Esumi1, H Ohgaki, E Kohzen, S Takayama, T Sugimura.   

Abstract

The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment.

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Year:  1989        PMID： 2516847      PMCID： PMC5917934          DOI： 10.1111/j.1349-7006.1989.tb01651.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]‐pyridine
  7 in total

1.  Successful use of short-term tests for academic purposes: their use in identification of new environmental carcinogens with possible risk for humans.

Authors:  T Sugimura
Journal:  Mutat Res       Date:  1988 May-Aug       Impact factor: 2.433

2.  Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose.

Authors:  M Shioya; K Wakabayashi; S Sato; M Nagao; T Sugimura
Journal:  Mutat Res       Date:  1987 Jul-Aug       Impact factor: 2.433

3.  Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite.

Authors:  J A Holme; H Wallin; G Brunborg; E J Søderlund; J K Hongslo; J Alexander
Journal:  Carcinogenesis       Date:  1989-08       Impact factor: 4.944

4.  4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat.

Authors:  J Alexander; H Wallin; J A Holme; G Becher
Journal:  Carcinogenesis       Date:  1989-08       Impact factor: 4.944

5.  The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Authors:  J S Felton; M G Knize; N H Shen; P R Lewis; B D Andresen; J Happe; F T Hatch
Journal:  Carcinogenesis       Date:  1986-07       Impact factor: 4.944

6.  Ranking animal carcinogens: a proposed regulatory approach.

Authors:  R A Squire
Journal:  Science       Date:  1981-11-20       Impact factor: 47.728

7.  DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.

Authors:  K Takayama; K Yamashita; K Wakabayashi; T Sugimura; M Nagao
Journal:  Jpn J Cancer Res       Date:  1989-12
  7 in total
  32 in total

1.  Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA.

Authors:  K Brown; B E Hingerty; E A Guenther; V V Krishnan; S Broyde; K W Turteltaub; M Cosman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

2.  A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.

Authors:  Chi Chen; Xiaochao Ma; Michael A Malfatti; Kristopher W Krausz; Shioko Kimura; James S Felton; Jeffrey R Idle; Frank J Gonzalez
Journal:  Chem Res Toxicol       Date:  2007-02-06       Impact factor: 3.739

3.  Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma.

Authors:  Yawei Zhang; Kathryn J Hughes; Shelia Hoar Zahm; Yaqun Zhang; Theodore R Holford; Li Dai; Yana Bai; Xuesong Han; Qin Qin; Qing Lan; Nathaniel Rothman; Yong Zhu; Brian Leaderer; Tongzhang Zheng
Journal:  Am J Epidemiol       Date:  2009-10-12       Impact factor: 4.897

4.  Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.

Authors:  Connie Cheung; Shea Loy; Guang Xun Li; Anna B Liu; Chung S Yang
Journal:  Carcinogenesis       Date:  2010-11-15       Impact factor: 4.944

5.  Introduction of cytochrome P450IA2 metabolic capability into cell lines genetically matched for DNA repair proficiency/deficiency.

Authors:  L H Thompson; R W Wu; J S Felton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

Review 6.  Animal models of colorectal cancer.

Authors:  Robert L Johnson; James C Fleet
Journal:  Cancer Metastasis Rev       Date:  2013-06       Impact factor: 9.264

7.  Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.

Authors:  Lindsay M Morton; Sophia S Wang; Wendy Cozen; Martha S Linet; Nilanjan Chatterjee; Scott Davis; Richard K Severson; Joanne S Colt; Mohammad A Vasef; Nathaniel Rothman; Aaron Blair; Leslie Bernstein; Amanda J Cross; Anneclaire J De Roos; Eric A Engels; David W Hein; Deirdre A Hill; Linda E Kelemen; Unhee Lim; Charles F Lynch; Maryjean Schenk; Sholom Wacholder; Mary H Ward; Shelia Hoar Zahm; Stephen J Chanock; James R Cerhan; Patricia Hartge
Journal:  Blood       Date:  2008-09-16       Impact factor: 22.113

8.  Non-covalent DNA groove-binding by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Authors:  G A Marsch; R L Ward; M Colvin; K W Turteltaub
Journal:  Nucleic Acids Res       Date:  1994-12-11       Impact factor: 16.971

9.  Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.

Authors:  Guangxun Li; Hong Wang; Anna B Liu; Connie Cheung; Kenneth R Reuhl; Maarten C Bosland; Chung S Yang
Journal:  Cancer Prev Res (Phila)       Date:  2012-05-11

10.  Grilled meat consumption and PhIP-DNA adducts in prostate carcinogenesis.

Authors:  Deliang Tang; Jason J Liu; Andrew Rundle; Christine Neslund-Dudas; Adnan T Savera; Cathryn H Bock; Nora L Nock; James J Yang; Benjamin A Rybicki
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2007-04       Impact factor: 4.254
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