Literature DB >> 2516840

DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.

K Takayama1, K Yamashita, K Wakabayashi, T Sugimura, M Nagao.   

Abstract

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine by weight in cooked foods. This mutagen was found to produce DNA adducts in all ten tested organs of rats using the 32P-postlabeling method. The level of DNA adducts in the pancreas, kidney and liver increased dose-dependently and feeding time-dependently up to four weeks. When diet containing 0.05% PhIP was given to rats for four weeks, levels of PhIP-DNA adducts were relatively high in the lung, pancreas and heart, being around 20 per 10(7) nucleotides, and lowest in the liver, being 2.20 per 10(7) nucleotides. Thus, PhIP showed a unique feature in the formation of DNA adducts compared to other mutagenic and carcinogenic heterocyclic amines, which produce the highest level of DNA adducts in the liver.

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Year:  1989        PMID： 2516840      PMCID： PMC5917929          DOI： 10.1111/j.1349-7006.1989.tb01644.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  14 in total

Review 1.  Studies on environmental chemical carcinogenesis in Japan.

Authors:  T Sugimura
Journal:  Science       Date:  1986-07-18       Impact factor: 47.728

Review 2.  New environmental carcinogens in daily life.

Authors:  T Sugimura
Journal:  Trends Pharmacol Sci       Date:  1988-06       Impact factor: 14.819

3.  Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods.

Authors:  X M Zhang; K Wakabayashi; Z C Liu; T Sugimura; M Nagao
Journal:  Mutat Res       Date:  1988-09       Impact factor: 2.433

4.  Heterocyclic amine-DNA adducts analyzed by 32P-postlabeling method.

Authors:  K Yamashita; A Umemoto; S Grivas; S Kato; S Sato; T Sugimura
Journal:  Nucleic Acids Symp Ser       Date:  1988

5.  Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity.

Authors:  L H Thompson; J D Tucker; S A Stewart; M L Christensen; E P Salazar; A V Carrano; J S Felton
Journal:  Mutagenesis       Date:  1987-11       Impact factor: 3.000

6.  Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose.

Authors:  M Shioya; K Wakabayashi; S Sato; M Nagao; T Sugimura
Journal:  Mutat Res       Date:  1987 Jul-Aug       Impact factor: 2.433

7.  Isolation and identification of mutagens from a fried Norwegian meat product.

Authors:  G Becher; M G Knize; I F Nes; J S Felton
Journal:  Carcinogenesis       Date:  1988-02       Impact factor: 4.944

8.  Use of the 32P-postlabeling method to detect DNA adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) in monkeys fed IQ: identification of the N-(deoxyguanosin-8-yl)-IQ adduct.

Authors:  E G Snyderwine; K Yamashita; R H Adamson; S Sato; M Nagao; T Sugimura; S S Thorgeirsson
Journal:  Carcinogenesis       Date:  1988-10       Impact factor: 4.944

9.  32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene.

Authors:  E Randerath; H P Agrawal; J A Weaver; C B Bordelon; K Randerath
Journal:  Carcinogenesis       Date:  1985-08       Impact factor: 4.944

10.  The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Authors:  J S Felton; M G Knize; N H Shen; P R Lewis; B D Andresen; J Happe; F T Hatch
Journal:  Carcinogenesis       Date:  1986-07       Impact factor: 4.944
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  14 in total

1.  Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA.

Authors:  K Brown; B E Hingerty; E A Guenther; V V Krishnan; S Broyde; K W Turteltaub; M Cosman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

2.  Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo.

Authors:  K Brown; E A Guenther; K H Dingley; M Cosman; C A Harvey; S J Shields; K W Turteltaub
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans.

Authors:  Michael A Malfatti; Edward A Kuhn; Kenneth W Turteltaub; Selwyn M Vickers; Eric H Jensen; Lori Strayer; Kristin E Anderson
Journal:  Chem Res Toxicol       Date:  2016-03-08       Impact factor: 3.739

4.  N-Acetyltransferase polymorphism and human cancer risk.

Authors:  X Yang; T Takeshita; K Morimoto
Journal:  Environ Health Prev Med       Date:  2000-01       Impact factor: 3.674

5.  Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.

Authors:  Feng Wang; Nicholas E DeMuro; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
Journal:  J Am Chem Soc       Date:  2006-08-09       Impact factor: 15.419

6.  Non-covalent DNA groove-binding by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Authors:  G A Marsch; R L Ward; M Colvin; K W Turteltaub
Journal:  Nucleic Acids Res       Date:  1994-12-11       Impact factor: 16.971

7.  DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme.

Authors:  Feng Wang; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
Journal:  Biochemistry       Date:  2007-06-30       Impact factor: 3.162

8.  Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters.

Authors:  H Nagaoka; K Wakabayashi; S B Kim; I S Kim; Y Tanaka; M Ochiai; A Tada; H Nukaya; T Sugimura; M Nagao
Journal:  Jpn J Cancer Res       Date:  1992-10

9.  Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.

Authors:  K Imaida; A Hagiwara; H Yada; T Masui; R Hasegawa; M Hirose; T Sugimura; N Ito; T Shirai
Journal:  Jpn J Cancer Res       Date:  1996-11

10.  Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.

Authors:  M Ochiai; K Ogawa; K Wakabayashi; T Sugimura; S Nagase; H Esumi; M Nagao
Journal:  Jpn J Cancer Res       Date:  1991-04
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