Literature DB >> 25168240

Role and therapeutic value of dendritic cells in central nervous system autoimmunity.

F J Quintana1, A Yeste1, I D Mascanfroni1.   

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells that control the generation of adaptive immunity. Consequently, DCs have a central role in the induction of protective immunity to pathogens and also in the pathogenic immune response responsible for the development and progression of autoimmune disorders. Thus the study of the molecular pathways that control DC development and function is likely to result in new strategies for the therapeutic manipulation of the immune response. In this review, we discuss the role and therapeutic value of DCs in autoimmune diseases, with a special focus on multiple sclerosis.

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Year:  2014        PMID： 25168240      PMCID： PMC4291485          DOI： 10.1038/cdd.2014.125

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  148 in total

1.  Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo.

Authors:  Abdelilah Wakkach; Nathalie Fournier; Valérie Brun; Jean-Philippe Breittmayer; Françoise Cottrez; Hervé Groux
Journal:  Immunity       Date:  2003-05       Impact factor: 31.745

2.  Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

Authors:  Melanie Greter; Frank L Heppner; Maria P Lemos; Bernhard M Odermatt; Norbert Goebels; Terri Laufer; Randolph J Noelle; Burkhard Becher
Journal:  Nat Med       Date:  2005-02-27       Impact factor: 53.440

3.  Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

Authors:  Eileen J McMahon; Samantha L Bailey; Carol Vanderlugt Castenada; Hanspeter Waldner; Stephen D Miller
Journal:  Nat Med       Date:  2005-02-27       Impact factor: 53.440

4.  Consequences of AhR activation in steady-state dendritic cells.

Authors:  Tom Simones; David M Shepherd
Journal:  Toxicol Sci       Date:  2010-11-19       Impact factor: 4.849

5.  Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Authors:  Angela Dann; Hendrik Poeck; Andrew L Croxford; Stefanie Gaupp; Katrin Kierdorf; Markus Knust; Dietmar Pfeifer; Cornelius Maihoefer; Stefan Endres; Ulrich Kalinke; Sven G Meuth; Heinz Wiendl; Klaus-Peter Knobeloch; Shizuo Akira; Ari Waisman; Gunther Hartmann; Marco Prinz
Journal:  Nat Neurosci       Date:  2011-12-04       Impact factor: 24.884

6.  Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells.

Authors:  Nir Yogev; Friederike Frommer; Dominika Lukas; Kordula Kautz-Neu; Khalad Karram; Daniele Ielo; Esther von Stebut; Hans-Christian Probst; Maries van den Broek; Dieter Riethmacher; Tal Birnberg; Thomas Blank; Boris Reizis; Thomas Korn; Heinz Wiendl; Steffen Jung; Marco Prinz; Florian C Kurschus; Ari Waisman
Journal:  Immunity       Date:  2012-08-16       Impact factor: 31.745

7.  Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency.

Authors:  Sen Wang; Yoshiyuki Miyazaki; Yukari Shinozaki; Hiroki Yoshida
Journal:  J Immunol       Date:  2007-11-15       Impact factor: 5.422

Review 8.  The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?

Authors:  Howard L Weiner
Journal:  Ann Neurol       Date:  2009-03       Impact factor: 10.422

9.  The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.

Authors:  Remko Schotte; Maho Nagasawa; Kees Weijer; Hergen Spits; Bianca Blom
Journal:  J Exp Med       Date:  2004-12-06       Impact factor: 14.307

10.  Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways.

Authors:  Vincent F-S Shih; Jeremy Davis-Turak; Monica Macal; Jenny Q Huang; Julia Ponomarenko; Jeffrey D Kearns; Tony Yu; Riku Fagerlund; Masataka Asagiri; Elina I Zuniga; Alexander Hoffmann
Journal:  Nat Immunol       Date:  2012-10-21       Impact factor: 25.606
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  19 in total

Review 1.  Role of AHR and HIF-1α in Glioblastoma Metabolism.

Authors:  Galina Gabriely; Michael A Wheeler; Maisa C Takenaka; Francisco J Quintana
Journal:  Trends Endocrinol Metab       Date:  2017-03-16       Impact factor: 12.015

Review 2.  Tolerogenic dendritic cells.

Authors:  Maisa C Takenaka; Francisco J Quintana
Journal:  Semin Immunopathol       Date:  2016-09-19       Impact factor: 9.623

3.  Tolerogenic nanoparticles suppress central nervous system inflammation.

Authors:  Jessica E Kenison; Aditi Jhaveri; Zhaorong Li; Nikita Khadse; Emily Tjon; Sara Tezza; Dominika Nowakowska; Agustin Plasencia; Vincent P Stanton; David H Sherr; Francisco J Quintana
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-25       Impact factor: 11.205

4.  Protein tyrosine phosphatase σ regulates autoimmune encephalomyelitis development.

Authors:  Yosuke Ohtake; Weimin Kong; Rashad Hussain; Makoto Horiuchi; Michel L Tremblay; Doina Ganea; Shuxin Li
Journal:  Brain Behav Immun       Date:  2017-05-27       Impact factor: 7.217

5.  Achieving Tolerance with Perforin-Secreting Dendritic Cells.

Authors:  Maisa C Takenaka; Francisco J Quintana
Journal:  Trends Mol Med       Date:  2015-12-12       Impact factor: 11.951

Review 6.  The Gut-CNS Axis in Multiple Sclerosis.

Authors:  Atsushi Kadowaki; Francisco J Quintana
Journal:  Trends Neurosci       Date:  2020-07-07       Impact factor: 13.837

Review 7.  Regulation of the Immune Response by the Aryl Hydrocarbon Receptor.

Authors:  Cristina Gutiérrez-Vázquez; Francisco J Quintana
Journal:  Immunity       Date:  2018-01-16       Impact factor: 31.745

Review 8.  Emerging roles of SIRT6 in human diseases and its modulators.

Authors:  Gang Liu; Haiying Chen; Hua Liu; Wenbo Zhang; Jia Zhou
Journal:  Med Res Rev       Date:  2020-12-16       Impact factor: 12.944

9.  Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.

Authors:  Benedetta Parodi; Alessia Sanna; Alessia Cedola; Antonio Uccelli; Nicole Kerlero de Rosbo
Journal:  Front Immunol       Date:  2021-05-18       Impact factor: 7.561

10.  From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function.

Authors:  A C Mendelsohn; L M Sanmarco; R G Spallanzani; D Brown; F J Quintana; S Breton; M A Battistone
Journal:  Am J Physiol Cell Physiol       Date:  2020-09-29       Impact factor: 4.249
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