Literature DB >> 26700492

Achieving Tolerance with Perforin-Secreting Dendritic Cells.

Maisa C Takenaka1, Francisco J Quintana2.   

Abstract

Dendritic cells (DCs) regulate the generation of effector adaptive immunity and enforce peripheral tolerance. In the October 2015 issue of Immunity, Zlotnikov-Klionsky et al. present exciting data describing a population of perforin-expressing CD11c(+)DCs that limit obesity as well as metabolic and autoimmune inflammation in mice.
Copyright © 2015. Published by Elsevier Ltd.

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Year:  2015        PMID： 26700492      PMCID： PMC4707090          DOI： 10.1016/j.molmed.2015.11.008

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

1.  Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7.

Authors:  Lior Zangi; Yael Zlotnikov Klionsky; Liran Yarimi; Esther Bachar-Lustig; Yaki Eidelstein; Elias Shezen; David Hagin; Yumi Ito; Toshiyuki Takai; Shlomit Reich-Zeliger; Assaf Lask; Oren Milstein; Steffen Jung; Vera Shinder; Yair Reisner
Journal:  Blood       Date:  2012-07-09       Impact factor: 22.113

2.  IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.

Authors:  Ivan D Mascanfroni; Ada Yeste; Silvio M Vieira; Evan J Burns; Bonny Patel; Ido Sloma; Yan Wu; Lior Mayo; Rotem Ben-Hamo; Sol Efroni; Vijay K Kuchroo; Simon C Robson; Francisco J Quintana
Journal:  Nat Immunol       Date:  2013-09-01       Impact factor: 25.606

Review 3.  Interleukin-10 and the interleukin-10 receptor.

Authors:  K W Moore; R de Waal Malefyt; R L Coffman; A O'Garra
Journal:  Annu Rev Immunol       Date:  2001       Impact factor: 28.527

Review 4.  Aryl hydrocarbon receptor control of adaptive immunity.

Authors:  Francisco J Quintana; David H Sherr
Journal:  Pharmacol Rev       Date:  2013-08-01       Impact factor: 25.468

5.  Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity.

Authors:  Yael Zlotnikov-Klionsky; Bar Nathansohn-Levi; Elias Shezen; Chava Rosen; Sivan Kagan; Liat Bar-On; Steffen Jung; Eric Shifrut; Shlomit Reich-Zeliger; Nir Friedman; Rina Aharoni; Ruth Arnon; Oren Yifa; Anna Aronovich; Yair Reisner
Journal:  Immunity       Date:  2015-09-15       Impact factor: 31.745

6.  Human T regulatory cells can use the perforin pathway to cause autologous target cell death.

Authors:  William J Grossman; James W Verbsky; Winfried Barchet; Marco Colonna; John P Atkinson; Timothy J Ley
Journal:  Immunity       Date:  2004-10       Impact factor: 31.745

7.  CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.

Authors:  Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Koji Eto; Hiroshi Yamashita; Mitsuru Ohsugi; Makoto Otsu; Kazuo Hara; Kohjiro Ueki; Seiryo Sugiura; Kotaro Yoshimura; Takashi Kadowaki; Ryozo Nagai
Journal:  Nat Med       Date:  2009-07-26       Impact factor: 53.440

8.  Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.

Authors:  Xuefang Cao; Sheng F Cai; Todd A Fehniger; Jiling Song; Lynne I Collins; David R Piwnica-Worms; Timothy J Ley
Journal:  Immunity       Date:  2007-10-04       Impact factor: 31.745

Review 9.  Role and therapeutic value of dendritic cells in central nervous system autoimmunity.

Authors:  F J Quintana; A Yeste; I D Mascanfroni
Journal:  Cell Death Differ       Date:  2014-08-29       Impact factor: 15.828

10.  Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.

Authors:  D Hawiger; K Inaba; Y Dorsett; M Guo; K Mahnke; M Rivera; J V Ravetch; R M Steinman; M C Nussenzweig
Journal:  J Exp Med       Date:  2001-09-17       Impact factor: 14.307
  10 in total
  1 in total

Review 1.  Tolerogenic dendritic cells.

Authors:  Maisa C Takenaka; Francisco J Quintana
Journal:  Semin Immunopathol       Date:  2016-09-19       Impact factor: 9.623
  1 in total

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