Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Emerging roles of SIRT6 in human diseases and its modulators.

Literature DB >> 33325563

Emerging roles of SIRT6 in human diseases and its modulators.

Gang Liu¹, Haiying Chen¹, Hua Liu², Wenbo Zhang², Jia Zhou¹.

Abstract

The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty-acylation, and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance. Over the past decades, the aberration of SIRT6 has been extensively observed in diverse life-threatening human diseases. In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways. Moreover, we discuss the advances in the development of small molecule SIRT6 modulators including activators and inhibitors as well as their pharmacological profiles toward potential therapeutics for SIRT6-mediated diseases.

Entities: Chemical

Keywords: SIRT6; activators; deacetylation; defatty-acylation; human diseases; inhibitors; mono-ADP-ribosylation; small molecule modulators

Mesh：

Substances：

Year: 2020 PMID： 33325563 PMCID： PMC7906922 DOI： 10.1002/med.21753

Source DB: PubMed Journal: Med Res Rev ISSN： 0198-6325 Impact factor: 12.944

326 in total

1. Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency.

Authors: Yuliang Tan; Yong Xue; Chunying Song; Michael Grunstein
Journal: Proc Natl Acad Sci U S A Date: 2013-06-24 Impact factor: 11.205

2. The sirtuin SIRT6 regulates lifespan in male mice.

Authors: Yariv Kanfi; Shoshana Naiman; Gail Amir; Victoria Peshti; Guy Zinman; Liat Nahum; Ziv Bar-Joseph; Haim Y Cohen
Journal: Nature Date: 2012-02-22 Impact factor: 49.962

3. USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.

Authors: Zhenghong Lin; Heeyoung Yang; Can Tan; Jinping Li; Zhaojian Liu; Qiu Quan; Sinyi Kong; Junsheng Ye; Beixue Gao; Deyu Fang
Journal: Cell Rep Date: 2013-12-12 Impact factor: 9.423

4. Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition.

Authors: Yibo Li; Xue Li; Allison Cole; Sarah McLaughlin; Wei Du
Journal: Cell Cycle Date: 2018-02-08 Impact factor: 4.534

5. Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.

Authors: Giovanna Sociali; Mirko Magnone; Silvia Ravera; Patrizia Damonte; Tiziana Vigliarolo; Maria Von Holtey; Valerio G Vellone; Enrico Millo; Irene Caffa; Michele Cea; Marco Daniele Parenti; Alberto Del Rio; Maximilien Murone; Raul Mostoslavsky; Alessia Grozio; Alessio Nencioni; Santina Bruzzone
Journal: FASEB J Date: 2017-04-06 Impact factor: 5.191

Review 6. Chromatin and beyond: the multitasking roles for SIRT6.

Authors: Sita Kugel; Raul Mostoslavsky
Journal: Trends Biochem Sci Date: 2014-01-14 Impact factor: 13.807

7. SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

Authors: Hualing Sun; Yanru Wu; Dongjie Fu; Yinchen Liu; Cui Huang
Journal: Stem Cells Date: 2014-07 Impact factor: 6.277

8. Sirtuin 6 modulates hypoxia-induced autophagy in nasal polyp fibroblasts via inhibition of glycolysis.

Authors: Chia-Tung Shun; Sze-Kwan Lin; Chi-Yuan Hong; Chih-Feng Lin; Chia-Ming Liu
Journal: Am J Rhinol Allergy Date: 2016-01-21 Impact factor: 2.467

9. Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.

Authors: Marcos C Carreira; Andrea G Izquierdo; Maria Amil; Felipe F Casanueva; Ana B Crujeiras
Journal: Oxid Med Cell Longev Date: 2018-12-23 Impact factor: 6.543

10. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.

Authors: Jia-Lin Shang; Shao-Bo Ning; Ying-Yi Chen; Tian-Xiang Chen; Jian Zhang
Journal: Acta Pharmacol Sin Date: 2020-06-15 Impact factor: 6.150

18 in total

1. Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway.

Authors: Xianbang Hou; Xueyuan Zhang; Jingting Bi; Anhong Zhu; Liwei He
Journal: J Nat Med Date: 2021-03-23 Impact factor: 2.343

2. Identification of a protective Bacteroides strain of alcoholic liver disease and its synergistic effect with pectin.

Authors: Qiangqiang Wang; Yating Li; Longxian Lv; Huiyong Jiang; Ren Yan; Shuting Wang; Yanmeng Lu; Zhengjie Wu; Jian Shen; Shiman Jiang; Jiawen Lv; Shengjie Li; Aoxiang Zhuge; Lanjuan Li
Journal: Appl Microbiol Biotechnol Date: 2022-05-13 Impact factor: 4.813

Emerging roles of SIRT6 in human diseases and its modulators.

1. Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency.

2. The sirtuin SIRT6 regulates lifespan in male mice.

3. USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.

4. Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition.

5. Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.

Review 6. Chromatin and beyond: the multitasking roles for SIRT6.

7. SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway.

8. Sirtuin 6 modulates hypoxia-induced autophagy in nasal polyp fibroblasts via inhibition of glycolysis.

9. Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.

10. MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer.

1. Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway.

2. Identification of a protective Bacteroides strain of alcoholic liver disease and its synergistic effect with pectin.

3. SIRT6 in Vascular Diseases, from Bench to Bedside.

4. SIRT6 promotes ferroptosis and attenuates glycolysis in pancreatic cancer through regulation of the NF-κB pathway.

Review 5. Mammalian Sirtuins and Their Relevance in Vascular Calcification.

6. Roles of SIRT6 in kidney disease: a novel therapeutic target.

Review 7. SIRT6 Widely Regulates Aging, Immunity, and Cancer.

Review 8. Sirtuin 6: linking longevity with genome and epigenome stability.

Review 9. Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo.

10. RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein.