Literature DB >> 25162801

Cancer gene discovery goes mobile.

Louise van der Weyden1, Marco Ranzani1, David J Adams1.   

Abstract

A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.

Entities:  

Mesh：

Year:  2014        PMID： 25162801     DOI： 10.1038/ng.3072

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  Human somatic cell mutagenesis creates genetically tractable sarcomas.

Authors:  Sam D Molyneux; Paul D Waterhouse; Dawne Shelton; Yang W Shao; Christopher M Watling; Qing-Lian Tang; Isaac S Harris; Brendan C Dickson; Pirashaanthy Tharmapalan; Geir K Sandve; Xiaoyang Zhang; Swneke D Bailey; Hal Berman; Jay S Wunder; Zsuzsanna Izsvák; Zsuzsanna Iszvak; Mathieu Lupien; Tak W Mak; Rama Khokha
Journal:  Nat Genet       Date:  2014-08-17       Impact factor: 38.330

2.  Signatures of mutation and selection in the cancer genome.

Authors:  Graham R Bignell; Chris D Greenman; Helen Davies; Adam P Butler; Sarah Edkins; Jenny M Andrews; Gemma Buck; Lina Chen; David Beare; Calli Latimer; Sara Widaa; Jonathon Hinton; Ciara Fahey; Beiyuan Fu; Sajani Swamy; Gillian L Dalgliesh; Bin T Teh; Panos Deloukas; Fengtang Yang; Peter J Campbell; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962

Review 3.  Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice.

Authors:  Annapoorni Rangarajan; Robert A Weinberg
Journal:  Nat Rev Cancer       Date:  2003-12       Impact factor: 60.716

4.  TERT promoter mutations in familial and sporadic melanoma.

Authors:  Susanne Horn; Adina Figl; P Sivaramakrishna Rachakonda; Christine Fischer; Antje Sucker; Andreas Gast; Stephanie Kadel; Iris Moll; Eduardo Nagore; Kari Hemminki; Dirk Schadendorf; Rajiv Kumar
Journal:  Science       Date:  2013-01-24       Impact factor: 47.728

Review 5.  Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.

Authors:  Christoph Plass; Stefan M Pfister; Anders M Lindroth; Olga Bogatyrova; Rainer Claus; Peter Lichter
Journal:  Nat Rev Genet       Date:  2013-10-09       Impact factor: 53.242

6.  Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.

Authors:  R Nusse; A van Ooyen; D Cox; Y K Fung; H Varmus
Journal:  Nature       Date:  1984 Jan 12-18       Impact factor: 49.962

7.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.

Authors:  Simon A Forbes; Nidhi Bindal; Sally Bamford; Charlotte Cole; Chai Yin Kok; David Beare; Mingming Jia; Rebecca Shepherd; Kenric Leung; Andrew Menzies; Jon W Teague; Peter J Campbell; Michael R Stratton; P Andrew Futreal
Journal:  Nucleic Acids Res       Date:  2010-10-15       Impact factor: 16.971

8.  A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone.

Authors:  Laure Thibaudeau; Anna V Taubenberger; Boris M Holzapfel; Verena M Quent; Tobias Fuehrmann; Parisa Hesami; Toby D Brown; Paul D Dalton; Carl A Power; Brett G Hollier; Dietmar W Hutmacher
Journal:  Dis Model Mech       Date:  2014-02       Impact factor: 5.758

Review 9.  Realizing the promise of cancer predisposition genes.

Authors:  Nazneen Rahman
Journal:  Nature       Date:  2014-01-16       Impact factor: 49.962

10.  An integrated encyclopedia of DNA elements in the human genome.

Authors: 
Journal:  Nature       Date:  2012-09-06       Impact factor: 49.962
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