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Literature DB >> 24429628

Realizing the promise of cancer predisposition genes.

Abstract

Genes in which germline mutations confer highly or moderately increased risks of cancer are called cancer predisposition genes. More than 100 of these genes have been identified, providing important scientific insights in many areas, particularly the mechanisms of cancer causation. Moreover, clinical utilization of cancer predisposition genes has had a substantial impact on diagnosis, optimized management and prevention of cancer. The recent transformative advances in DNA sequencing hold the promise of many more cancer predisposition gene discoveries, and greater and broader clinical applications. However, there is also considerable potential for incorrect inferences and inappropriate clinical applications. Realizing the promise of cancer predisposition genes for science and medicine will thus require careful navigation.

Entities: Chemical

Mesh：

Year: 2014 PMID： 24429628 PMCID： PMC4975511 DOI： 10.1038/nature12981

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

109 in total

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8. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.

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Journal: Nat Genet Date: 2005-09-18 Impact factor: 38.330

204 in total

Review 1. Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease.

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Review 2. Population genetic testing for cancer susceptibility: founder mutations to genomes.

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3. Radiogenomic Predictors of Adverse Effects following Charged Particle Therapy.

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4. Endogenous network states predict gain or loss of functions for genetic mutations in hepatocellular carcinoma.

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5. High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients.

Authors: Justin Chen; Maria K Haanpää; Joshua J Gruber; Natalie Jäger; James M Ford; Michael P Snyder
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6. Germline RAD51B truncating mutation in a family with cutaneous melanoma.

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Journal: Fam Cancer Date: 2015-06 Impact factor: 2.375

7. Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

Authors: Zhaoming Wang; Carmen L Wilson; John Easton; Andrew Thrasher; Heather Mulder; Qi Liu; Dale J Hedges; Shuoguo Wang; Michael C Rusch; Michael N Edmonson; Shawn Levy; Jennifer Q Lanctot; Eric Caron; Kyla Shelton; Kelsey Currie; Matthew Lear; Aman Patel; Celeste Rosencrance; Ying Shao; Bhavin Vadodaria; Donald Yergeau; Yadav Sapkota; Russell J Brooke; Wonjong Moon; Evadnie Rampersaud; Xiaotu Ma; Ti-Cheng Chang; Stephen V Rice; Cynthia Pepper; Xin Zhou; Xiang Chen; Wenan Chen; Angela Jones; Braden Boone; Matthew J Ehrhardt; Matthew J Krasin; Rebecca M Howell; Nicholas S Phillips; Courtney Lewis; Deokumar Srivastava; Ching-Hon Pui; Chimene A Kesserwan; Gang Wu; Kim E Nichols; James R Downing; Melissa M Hudson; Yutaka Yasui; Leslie L Robison; Jinghui Zhang
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8. HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: Metastatic pheochromocytomas and paragangliomas: proceedings of the MEN2019 workshop.

Authors: Patricia L M Dahia; Roderick Clifton-Bligh; Anne-Paule Gimenez-Roqueplo; Mercedes Robledo; Camilo Jimenez
Journal: Endocr Relat Cancer Date: 2020-08 Impact factor: 5.678

Review 9. Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.

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Journal: Physiol Genomics Date: 2014-08-05 Impact factor: 3.107

10. Mainstreaming genetic testing of cancer predisposition genes.

Authors: Nazneen Rahman
Journal: Clin Med (Lond) Date: 2014-08 Impact factor: 2.659