PURPOSE: Cervical spondylotic myelopathy (CSM) is a common spinal cord disorder in the elderly. Diffusion tensor imaging (DTI) has been shown to be of great value for evaluating the microstructure of nerve tracts in the spinal cord. Currently, the quantitative assessment of the degeneration on the specific tracts in CSM is still rare. The aim of the present study was to use tractography-based quantification to investigate the column-specific degeneration in CSM. METHODS: A total of 43 volunteers were recruited with written informed consent, including 20 healthy subjects and 23 CSM patients. Diffusion MRI was taken by 3T MRI scanner. Fiber tractography was performed using TrackVis to reconstruct the white matter tracts of the anterior, lateral and posterior column on the bilateral sides. The DTI metrics acquired from tractography, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), were compared between healthy subjects and CSM patients. RESULTS: Compared to healthy subjects, FA was found significantly lower in the lateral (Healthy 0.64 ± 0.07 vs. CSM 0.53 ± 0.08) and posterior column (Healthy 0.67 ± 0.08 vs. CSM 0.47 ± 0.08) (p < 0.001), while MD, AD and RD were significantly higher in the anterior, lateral and posterior column in CSM (p < 0.05). CONCLUSION: Loss of microstructural integrity was detected in the lateral and posterior column in CSM. Tractography-based quantification was capable of evaluating the subtle pathological insult within white matter on a column-specific basis, which exhibited potential clinical value for in vivo evaluation of the severity of CSM.
PURPOSE: Cervical spondylotic myelopathy (CSM) is a common spinal cord disorder in the elderly. Diffusion tensor imaging (DTI) has been shown to be of great value for evaluating the microstructure of nerve tracts in the spinal cord. Currently, the quantitative assessment of the degeneration on the specific tracts in CSM is still rare. The aim of the present study was to use tractography-based quantification to investigate the column-specific degeneration in CSM. METHODS: A total of 43 volunteers were recruited with written informed consent, including 20 healthy subjects and 23 CSM patients. Diffusion MRI was taken by 3T MRI scanner. Fiber tractography was performed using TrackVis to reconstruct the white matter tracts of the anterior, lateral and posterior column on the bilateral sides. The DTI metrics acquired from tractography, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), were compared between healthy subjects and CSM patients. RESULTS: Compared to healthy subjects, FA was found significantly lower in the lateral (Healthy 0.64 ± 0.07 vs. CSM 0.53 ± 0.08) and posterior column (Healthy 0.67 ± 0.08 vs. CSM 0.47 ± 0.08) (p < 0.001), while MD, AD and RD were significantly higher in the anterior, lateral and posterior column in CSM (p < 0.05). CONCLUSION: Loss of microstructural integrity was detected in the lateral and posterior column in CSM. Tractography-based quantification was capable of evaluating the subtle pathological insult within white matter on a column-specific basis, which exhibited potential clinical value for in vivo evaluation of the severity of CSM.
Authors: M Xiangshui; C Xiangjun; Z Xiaoming; Z Qingshi; C Yi; Q Chuanqiang; M Xiangxing; L Chuanfu; H Jinwen Journal: Clin Radiol Date: 2010-04-18 Impact factor: 2.350
Authors: Joon Woo Lee; Jae Hyoung Kim; Jong Bin Park; Kun Woo Park; Jin S Yeom; Guen Young Lee; Heung Sik Kang Journal: Skeletal Radiol Date: 2011-04-15 Impact factor: 2.199
Authors: P W Stroman; C Wheeler-Kingshott; M Bacon; J M Schwab; R Bosma; J Brooks; D Cadotte; T Carlstedt; O Ciccarelli; J Cohen-Adad; A Curt; N Evangelou; M G Fehlings; M Filippi; B J Kelley; S Kollias; A Mackay; C A Porro; S Smith; S M Strittmatter; P Summers; I Tracey Journal: Neuroimage Date: 2013-05-14 Impact factor: 6.556
Authors: Chun Yi Wen; Jiao Long Cui; Harris S Liu; Kin Cheung Mak; Wai Yuen Cheung; Keith D K Luk; Yong Hu Journal: Radiology Date: 2013-10-28 Impact factor: 11.105
Authors: Tomasz Tykocki; Philip English; David Minks; Arunkumar Krishnakumar; Guy Wynne-Jones Journal: Neuroradiology Date: 2018-09-19 Impact factor: 2.804
Authors: Benjamin S Hopkins; Kenneth A Weber; Kartik Kesavabhotla; Monica Paliwal; Donald R Cantrell; Zachary A Smith Journal: World Neurosurg Date: 2019-03-25 Impact factor: 2.104
Authors: B B Reynolds; S By; Q R Weinberg; A A Witt; A T Newton; H R Feiler; B Ramkorun; D B Clayton; P Couture; J E Martus; M Adams; J C Wellons; S A Smith; A Bhatia Journal: AJNR Am J Neuroradiol Date: 2019-06-13 Impact factor: 3.825
Authors: Allan R Martin; Izabela Aleksanderek; Julien Cohen-Adad; Zenovia Tarmohamed; Lindsay Tetreault; Nathaniel Smith; David W Cadotte; Adrian Crawley; Howard Ginsberg; David J Mikulis; Michael G Fehlings Journal: Neuroimage Clin Date: 2015-12-04 Impact factor: 4.881
Authors: Jan Valošek; Petr Bednařík; Miloš Keřkovský; Petr Hluštík; Josef Bednařík; Alena Svatkova Journal: J Clin Med Date: 2022-04-20 Impact factor: 4.964
Authors: Gergely David; Siawoosh Mohammadi; Allan R Martin; Julien Cohen-Adad; Nikolaus Weiskopf; Alan Thompson; Patrick Freund Journal: Nat Rev Neurol Date: 2019-10-31 Impact factor: 42.937
Authors: Benjamin S Hopkins; Kenneth A Weber; Michael Brendan Cloney; Monica Paliwal; Todd B Parrish; Zachary A Smith Journal: Spine (Phila Pa 1976) Date: 2018-10-15 Impact factor: 3.241