Literature DB >> 25147149

Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation.

Kewal Kumar1, Sarah Schniper2, Antonio González-Sarrías3, Alvin A Holder4, Natalie Sanders5, David Sullivan5, William L Jarrett6, Krystyn Davis7, Fengwei Bai7, Navindra P Seeram3, Vipan Kumar8.   

Abstract

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  7-Chloroquinoline thiosemicarbazone; Anti-plasmodial activity; Cytotoxic activity; Gallium(III) complex; Selectivity index

Mesh：

Substances：

Year:  2014        PMID： 25147149     DOI： 10.1016/j.ejmech.2014.08.054

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  5 in total

1.  Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors.

Authors:  Myrna Hurtado; Umesh T Sankpal; Aboubacar Kaba; Shahela Mahammad; Jaya Chhabra; Deondra T Brown; Raj K Gurung; Alvin A Holder; Jamboor K Vishwanatha; Riyaz Basha
Journal:  Cell Physiol Biochem       Date:  2018-11-30

2.  A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.

Authors:  Shayna Sandhaus; Rosella Taylor; Tiffany Edwards; Alexis Huddleston; Ykeysha Wooten; Ramaiyer Venkatraman; Ralph T Weber; Antonio González-Sarrías; Patrick M Martin; Patrice Cagle; Yuk-Ching Tse-Dinh; Stephen J Beebe; Navindra Seeram; Alvin A Holder
Journal:  Inorg Chem Commun       Date:  2016-02       Impact factor: 2.495

3.  Synthesis, crystal structure and antiproliferative mechanisms of gallium(iii) complexes with benzoylpyridine thiosemicarbazones.

Authors:  Jinxu Qi; Taichen Liu; Wei Zhao; Xinhua Zheng; Yihong Wang
Journal:  RSC Adv       Date:  2020-05-18       Impact factor: 4.036

4.  3-Methyl-1-{(E)-[1-(4-methyl-pyridin-2-yl)ethyl-idene]amino}-thio-urea: crystal structure and Hirshfeld surface analysis.

Authors:  Lee Chin Lai; Che Nursarah Binti Che Abdul Rahman; M Ibrahim M Tahir; Thahira B S A Ravoof; Mukesh M Jotani; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-01-31

5.  Cu(ii), Ga(iii) and In(iii) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities.

Authors:  Yu-Ting Wang; Yan Fang; Meng Zhao; Ming-Xue Li; Yu-Mei Ji; Qiu-Xia Han
Journal:  Medchemcomm       Date:  2017-10-09       Impact factor: 3.597
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.