| Literature DB >> 25142458 |
Amanda J Kiliaan1, Ilse A C Arnoldussen1, Deborah R Gustafson2.
Abstract
Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body-mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood-brain barrier integrity, and risk of all-cause late-onset dementia and Alzheimer's disease. This observation leads us to question what it is about body-mass index that is associated with health of the brain and dementia risk. If high body-mass index and central adiposity represent an increase in adipose tissue, then the endocrine function of adipose tissue, mediated by adipose tissue hormones and adipokines, could be a clue to mechanisms that underlie the association with dementia and Alzheimer's disease. Hundreds of adipokines have been identified, creating a complexity that is a challenge to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, and with imaging-based measures of brain volume, structure, and function in human beings and in preclinical models of clinical dementia.Entities:
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Year: 2014 PMID： 25142458 PMCID： PMC4228955 DOI： 10.1016/S1474-4422(14)70085-7
Source DB: PubMed Journal: Lancet Neurol ISSN： 1474-4422 Impact factor: 44.182