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Literature DB >> 28478593

Weight Loss in Patients with Dementia: Considering the Potential Impact of Pharmacotherapy.

Bart A A Franx¹, Ilse A C Arnoldussen¹, Amanda J Kiliaan¹, Deborah R Gustafson^2,3,4.

Abstract

Unintentional body weight loss is common in patients with dementia and is linked to cognitive impairment and poorer disease outcomes. It is proposed that some dementia medications with market approval, while aiming to improve cognitive and functional outcomes of a patient with dementia, are associated with reported body weight or body mass index loss. This review presents evidence in the published literature on body weight loss in dementia, describes selected theories behind body weight loss, evaluates the potential impact of approved dementia pharmacotherapies on body weight, considers the potential role for medical foods, understands the potential influence of treatments for neuropsychiatric symptoms and signs, and finally, summarizes this important area.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2017 PMID： 28478593 PMCID： PMC6779159 DOI： 10.1007/s40266-017-0462-x

Source DB: PubMed Journal: Drugs Aging ISSN： 1170-229X Impact factor: 3.923

166 in total

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Authors: R McShane; A Areosa Sastre; N Minakaran
Journal: Cochrane Database Syst Rev Date: 2006-04-19

2. Daily energy expenditure in free-living non-institutionalized Alzheimer's patients: a doubly labeled water study.

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Journal: Neurology Date: 1997-04 Impact factor: 9.910

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Journal: Age Ageing Date: 1989-05 Impact factor: 10.668

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Authors: K J Anstey; N Cherbuin; M Budge; J Young
Journal: Obes Rev Date: 2011-02-23 Impact factor: 9.213

Review 5. An approach to the management of unintentional weight loss in elderly people.

Authors: Shabbir M H Alibhai; Carol Greenwood; Hélène Payette
Journal: CMAJ Date: 2005-03-15 Impact factor: 8.262

6. Adiposity indicators and dementia over 32 years in Sweden.

Authors: D R Gustafson; K Bäckman; M Waern; S Ostling; X Guo; P Zandi; M M Mielke; C Bengtsson; I Skoog
Journal: Neurology Date: 2009-11-10 Impact factor: 9.910

Review 7. Leptin regulation of hippocampal synaptic function in health and disease.

Authors: Andrew J Irving; Jenni Harvey
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2013-12-02 Impact factor: 6.237

8. Influence of antidepressant therapies on weight and appetite in the elderly.

Authors: P Thomas; C Hazif-Thomas; J-P Clement
Journal: J Nutr Health Aging Date: 2003 Impact factor: 4.075

9. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort.

Authors: Anna-Maija Tolppanen; Tiia Ngandu; Ingemar Kåreholt; Tiina Laatikainen; Minna Rusanen; Hilkka Soininen; Miia Kivipelto
Journal: J Alzheimers Dis Date: 2014 Impact factor: 4.472

10. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice.

Authors: Maximilian Wiesmann; Valerio Zerbi; Diane Jansen; Roy Haast; Dieter Lütjohann; Laus M Broersen; Arend Heerschap; Amanda J Kiliaan
Journal: Neural Plast Date: 2016-03-10 Impact factor: 3.599

9 in total

1. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Authors: Ganesh M Babulal; Yakeel T Quiroz; Benedict C Albensi; Eider Arenaza-Urquijo; Arlene J Astell; Claudio Babiloni; Alex Bahar-Fuchs; Joanne Bell; Gene L Bowman; Adam M Brickman; Gaël Chételat; Carrie Ciro; Ann D Cohen; Peggye Dilworth-Anderson; Hiroko H Dodge; Simone Dreux; Steven Edland; Anna Esbensen; Lisbeth Evered; Michael Ewers; Keith N Fargo; Juan Fortea; Hector Gonzalez; Deborah R Gustafson; Elizabeth Head; James A Hendrix; Scott M Hofer; Leigh A Johnson; Roos Jutten; Kerry Kilborn; Krista L Lanctôt; Jennifer J Manly; Ralph N Martins; Michelle M Mielke; Martha Clare Morris; Melissa E Murray; Esther S Oh; Mario A Parra; Robert A Rissman; Catherine M Roe; Octavio A Santos; Nikolaos Scarmeas; Lon S Schneider; Nicole Schupf; Sietske Sikkes; Heather M Snyder; Hamid R Sohrabi; Yaakov Stern; Andre Strydom; Yi Tang; Graciela Muniz Terrera; Charlotte Teunissen; Debora Melo van Lent; Michael Weinborn; Linda Wesselman; Donna M Wilcock; Henrik Zetterberg; Sid E O'Bryant
Journal: Alzheimers Dement Date: 2018-12-13 Impact factor: 21.566

8. Commentary on Lahiri et al. Weight and Body Mass Index Change After Switching to Integrase Inhibitors or Tenofovir Alafenamide Among Women Living with HIV.

Authors: Francesca Macaluso; Deborah R Gustafson
Journal: J AIDS HIV Treat Date: 2021

9. Amyloid-β Impairs Dendritic Trafficking of Golgi-Like Organelles in the Early Phase Preceding Neurite Atrophy: Rescue by Mirtazapine.

Authors: Elsa Fabbretti; Giulia Antognolli; Enrico Tongiorgi
Journal: Front Mol Neurosci Date: 2021-06-03 Impact factor: 5.639