Polyxeni Karakosta1,2, Katerina Margetaki1, Eleni Fthenou3, Mariza Kampouri1, Andriani Kyriklaki1, Katerina Koutra4, Georgia Chalkiadaki1, Theano Roumeliotaki1, Marina Vafeiadi1, Manolis Kogevinas5, Christos Mantzoros6, Lida Chatzi7. 1. Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Greece. 2. Clinical Microbiology Laboratory, Attikon University Hospital, National and Kapodistrian University of Athens, Greece. 3. Qatar Biobank for Medical Research, Qatar Foundation for Education, Science, and Community Development, Doha, Qatar. 4. Department of Psychology, School of Social Sciences, University of Crete, Rethymnon, Greece. 5. Centre for Research in Environmental Epidemiology, Barcelona Institute for Global Health, Barcelona, Spain. 6. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard University, Boston, Massachusetts, USA. 7. Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Abstract
OBJECTIVE: Leptin is critical for central nervous system development and maturation. This study aimed to evaluate the potential regulatory role of cord leptin in the neuropsychomotor development of children ages 18 months to 6 years. METHODS: This study included 424 children from a prospective mother-child cohort (Rhea Study; Crete, Greece) with available cord leptin levels and data on neurodevelopmental outcomes at 18 months (Bayley Scales of Infant and Toddler Development, Third Edition), 4 years (McCarthy Scales of Children's Abilities), and 6 years (Raven's Coloured Progressive Matrices and Trail Making Test). Multivariable linear regression models were used to explore the associations. RESULTS: Each 10-ng/mL increase in the cord leptin level was associated with increased scores on the gross motor scale at 18 months (β coefficient: 3.8; 95% CI: 0.0-7.5), with decreased scores in the general cognitive performance (β coefficient: -3.0; 95% CI: -5.5 to -0.4), perceptual performance (β coefficient: -3.4; 95% CI: -6.0 to -9.9), working memory (β coefficient: -3.1; 95% CI: -5.7 to -0.4), executive function (β coefficient -3.1; 95% CI: -5.7 to -0.5), and functions of the posterior cortex (β coefficient: -2.7; 95% CI: -5.2 to -0.1) scales at 4 years, and with a 3.7-unit decrease in the Raven's Coloured Progressive Matrices score at 6 years (β coefficient: -3.7; 95% CI: -6.9 to -0.5). CONCLUSIONS: Increased cord leptin levels are associated with enhanced gross motor development at 18 months but decreased cognitive performance in early and middle childhood.
OBJECTIVE:Leptin is critical for central nervous system development and maturation. This study aimed to evaluate the potential regulatory role of cord leptin in the neuropsychomotor development of children ages 18 months to 6 years. METHODS: This study included 424 children from a prospective mother-child cohort (Rhea Study; Crete, Greece) with available cord leptin levels and data on neurodevelopmental outcomes at 18 months (Bayley Scales of Infant and Toddler Development, Third Edition), 4 years (McCarthy Scales of Children's Abilities), and 6 years (Raven's Coloured Progressive Matrices and Trail Making Test). Multivariable linear regression models were used to explore the associations. RESULTS: Each 10-ng/mL increase in the cord leptin level was associated with increased scores on the gross motor scale at 18 months (β coefficient: 3.8; 95% CI: 0.0-7.5), with decreased scores in the general cognitive performance (β coefficient: -3.0; 95% CI: -5.5 to -0.4), perceptual performance (β coefficient: -3.4; 95% CI: -6.0 to -9.9), working memory (β coefficient: -3.1; 95% CI: -5.7 to -0.4), executive function (β coefficient -3.1; 95% CI: -5.7 to -0.5), and functions of the posterior cortex (β coefficient: -2.7; 95% CI: -5.2 to -0.1) scales at 4 years, and with a 3.7-unit decrease in the Raven's Coloured Progressive Matrices score at 6 years (β coefficient: -3.7; 95% CI: -6.9 to -0.5). CONCLUSIONS: Increased cord leptin levels are associated with enhanced gross motor development at 18 months but decreased cognitive performance in early and middle childhood.
Authors: Ana Cristina R Camargos; Vanessa A Mendonça; Katherine S C Oliveira; Camila Alves de Andrade; Hércules Ribeiro Leite; Sueli Ferreira da Fonseca; Erica Leandro Marciano Vieira; Antônio Lúcio Teixeira Júnior; Ana Cristina Rodrigues Lacerda Journal: Behav Brain Res Date: 2017-02-24 Impact factor: 3.332