Literature DB >> 25131777

One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response.

Geetha Kannan1, Emese Prandovszky2, Curtis B Steinfeldt2, Kristin L Gressitt2, ChunXia Yang3, Robert H Yolken2, Emily G Severance2, Lorraine Jones-Brando2, Mikhail V Pletnikov4.   

Abstract

We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Animal models; Behavior; Cysts; Immune response; Inactivation; Toxoplasma

Mesh：

Substances：

Year:  2014        PMID： 25131777      PMCID： PMC4435842          DOI： 10.1016/j.exppara.2014.08.001

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  23 in total

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2.  NIH Image to ImageJ: 25 years of image analysis.

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Review 3.  Mouse models of gene-environment interactions in schizophrenia.

Authors:  Geetha Kannan; Akira Sawa; Mikhail V Pletnikov
Journal:  Neurobiol Dis       Date:  2013-06-05       Impact factor: 5.996

4.  Toxoplasma gondii strain-dependent effects on mouse behaviour.

Authors:  Geetha Kannan; Krisztina Moldovan; Jian-Chun Xiao; Robert H Yolken; Lorraine Jones-Brando; Mikhail V Pletnikov
Journal:  Folia Parasitol (Praha)       Date:  2010-06       Impact factor: 2.122

5.  Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.

Authors:  John G D'Angelo; Claudia Bordón; Gary H Posner; Robert Yolken; Lorraine Jones-Brando
Journal:  J Antimicrob Chemother       Date:  2008-11-06       Impact factor: 5.790

6.  Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring.

Authors:  Jianchun Xiao; Stephen L Buka; Tyrone D Cannon; Yasuhiro Suzuki; Raphael P Viscidi; E Fuller Torrey; Robert H Yolken
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Authors:  Józef Kur; Lucyna Holec-Gasior; Elzbieta Hiszczyńska-Sawicka
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Review 8.  Toxoplasma gondii and cognitive deficits in schizophrenia: an animal model perspective.

Authors:  Geetha Kannan; Mikhail V Pletnikov
Journal:  Schizophr Bull       Date:  2012-09-01       Impact factor: 9.306

9.  Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models.

Authors:  Ying Zhao; Bo Huang; Shiguang Huang; Huanqin Zheng; Yun-quan Li; Zhao-rong Lun; Jilong Shen; Yong Wang; Lloyd H Kasper; Fangli Lu
Journal:  Parasitol Res       Date:  2013-06-20       Impact factor: 2.289

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Journal:  PLoS One       Date:  2013-09-18       Impact factor: 3.240
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  5 in total

Review 1.  A review on inactivation methods of Toxoplasma gondii in foods.

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Journal:  Pathog Glob Health       Date:  2018-10-22       Impact factor: 2.894

2.  Oral inoculation of ultraviolet-irradiated Eimeria species oocysts protects chickens against coccidiosis.

Authors:  Saeed A El-Ashram; Shawky M Aboelhadid; Sahar M Gadelhaq; Walid M Arafa; Abdel-Razik H Abdel-Razik; Salama Abohamra; Khaled T Abdelaziz
Journal:  Parasitol Res       Date:  2019-10-12       Impact factor: 2.289

3.  Chronic Toxoplasma gondii Infection Induces Anti-N-Methyl-d-Aspartate Receptor Autoantibodies and Associated Behavioral Changes and Neuropathology.

Authors:  Ye Li; Raphael P Viscidi; Geetha Kannan; Ross McFarland; Mikhail V Pletnikov; Emily G Severance; Robert H Yolken; Jianchun Xiao
Journal:  Infect Immun       Date:  2018-09-21       Impact factor: 3.441

Review 4.  Toxoplasma gondii in Foods: Prevalence, Control, and Safety.

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Journal:  Foods       Date:  2022-08-22

5.  Pathogen-mediated NMDA receptor autoimmunity and cellular barrier dysfunction in schizophrenia.

Authors:  G Kannan; K L Gressitt; S Yang; C R Stallings; E Katsafanas; L A Schweinfurth; C L G Savage; M B Adamos; K M Sweeney; A E Origoni; S Khushalani; S Bahn; F M Leweke; F B Dickerson; R H Yolken; M V Pletnikov; E G Severance
Journal:  Transl Psychiatry       Date:  2017-08-01       Impact factor: 6.222
  5 in total

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