Literature DB >> 22941742

Toxoplasma gondii and cognitive deficits in schizophrenia: an animal model perspective.

Geetha Kannan1, Mikhail V Pletnikov.   

Abstract

Cognitive deficits are a core feature of schizophrenia. Epidemiological evidence indicates that microbial pathogens may contribute to cognitive impairment in patients with schizophrenia. Exposure to Toxoplasma gondii (T. gondii) has been associated with cognitive deficits in humans. However, the mechanisms whereby the parasite impacts cognition remain poorly understood. Animal models of T. gondii infection may aid in elucidating the underpinnings of cognitive dysfunction. Here, we (1) overview the literature on the association of T. gondii infection and cognitive impairment, (2) critically analyze current rodent models of cognitive deficits resulting from T. gondii infection, and (3) explore possible mechanisms whereby the parasite may affect cognitive function.

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Year:  2012        PMID： 22941742      PMCID： PMC3494063          DOI： 10.1093/schbul/sbs079

Source DB:  PubMed          Journal:  Schizophr Bull        ISSN： 0586-7614            Impact factor:   9.306


  50 in total

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Review 2.  From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment.

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Journal:  Neuropsychopharmacology       Date:  2011-09-28       Impact factor: 7.853

Review 3.  Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host.

Authors:  Jeroen P J Saeij; Jon P Boyle; John C Boothroyd
Journal:  Trends Parasitol       Date:  2005-10

4.  Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice.

Authors:  J Xiao; G Kannan; L Jones-Brando; C Brannock; I N Krasnova; J L Cadet; M Pletnikov; R H Yolken
Journal:  Neuroscience       Date:  2012-01-03       Impact factor: 3.590

5.  Infection with Toxoplasma gondii RH and Prugniaud strains in mice, rats and nude rats: kinetics of infection in blood and tissues related to pathology in acute and chronic infection.

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Journal:  Pathol Res Pract       Date:  1999       Impact factor: 3.250

6.  Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.

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7.  Congenital infection of mice with Toxoplasma gondii induces minimal change in behavior and no change in neurotransmitter concentrations.

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Journal:  J Parasitol       Date:  2012-04-02       Impact factor: 1.276

Review 8.  Evidence for a cytokine model of cognitive function.

Authors:  J McAfoose; B T Baune
Journal:  Neurosci Biobehav Rev       Date:  2008-10-18       Impact factor: 8.989

9.  Sex-determined resistance to Toxoplasma gondii is associated with temporal differences in cytokine production.

Authors:  C W Roberts; S M Cruickshank; J Alexander
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441

10.  The neurotropic parasite Toxoplasma gondii increases dopamine metabolism.

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Journal:  PLoS One       Date:  2011-09-21       Impact factor: 3.240
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  25 in total

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Authors:  Keith A Feigenson; Alex W Kusnecov; Steven M Silverstein
Journal:  Neurosci Biobehav Rev       Date:  2013-11-15       Impact factor: 8.989

3.  Cerebral complement C1q activation in chronic Toxoplasma infection.

Authors:  Jianchun Xiao; Ye Li; Kristin L Gressitt; Helen He; Geetha Kannan; Tracey L Schultz; Nadezhda Svezhova; Vern B Carruthers; Mikhail V Pletnikov; Robert H Yolken; Emily G Severance
Journal:  Brain Behav Immun       Date:  2016-04-22       Impact factor: 7.217

4.  Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice.

Authors:  Robert H Yolken; Lorraine Jones-Brando; David D Dunigan; Geetha Kannan; Faith Dickerson; Emily Severance; Sarven Sabunciyan; C Conover Talbot; Emese Prandovszky; James R Gurnon; Irina V Agarkova; Flora Leister; Kristin L Gressitt; Ou Chen; Bryan Deuber; Fangrui Ma; Mikhail V Pletnikov; James L Van Etten
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5.  Infection with Toxoplasma gondii does not elicit predator aversion in male mice nor increase their attractiveness in terms of mate choice.

Authors:  Linda Jing Ting Soh; Anand Vasudevan; Ajai Vyas
Journal:  Parasitol Res       Date:  2013-08-02       Impact factor: 2.289

Review 6.  Converging models of schizophrenia--Network alterations of prefrontal cortex underlying cognitive impairments.

Authors:  Takeshi Sakurai; Nao J Gamo; Takatoshi Hikida; Sun-Hong Kim; Toshiya Murai; Toshifumi Tomoda; Akira Sawa
Journal:  Prog Neurobiol       Date:  2015-09-25       Impact factor: 11.685

7.  Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii.

Authors:  Geetha Kannan; Joshua A Crawford; ChunXia Yang; Kristin L Gressitt; Chinezimuzo Ihenatu; Irina N Krasnova; Jean Lud Cadet; Robert H Yolken; Emily G Severance; Mikhail V Pletnikov
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8.  One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response.

Authors:  Geetha Kannan; Emese Prandovszky; Curtis B Steinfeldt; Kristin L Gressitt; ChunXia Yang; Robert H Yolken; Emily G Severance; Lorraine Jones-Brando; Mikhail V Pletnikov
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9.  Maternal T. gondii, offspring bipolar disorder and neurocognition.

Authors:  David Freedman; Yuanyuan Bao; Ling Shen; Catherine A Schaefer; Alan S Brown
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10.  Toxoplasma gondii Infection in Mice Impairs Long-Term Fear Memory Consolidation through Dysfunction of the Cortex and Amygdala.

Authors:  Fumiaki Ihara; Maki Nishimura; Yoshikage Muroi; Motamed Elsayed Mahmoud; Naoaki Yokoyama; Kisaburo Nagamune; Yoshifumi Nishikawa
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