Uduak U Andy1, Heidi S Harvie2, Mary F Ackenbom2, Lily A Arya2. 1. Department of OB/GYN, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Electronic address: uduak.umoh@uphs.upenn.edu. 2. Department of OB/GYN, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.
Abstract
OBJECTIVE: To compare the risk of postoperative infections in women who receive single-dose versus multi-dose prophylactic antibiotic regimen during prolapse surgery with mesh/graft. STUDY DESIGN: Retrospective cohort study of 460 women who underwent prolapse surgery with mesh/graft. We compared women who received a single-dose prophylactic antibiotic regimen to those who received a multi-dose regimen. The primary outcome was the presence of any postoperative infection, defined as the presence of any of the following infections: urinary tract infection (UTI), fever, wound or trocar site infection, mesh infection or pelvic abscess. Associations between prophylactic antibiotic regimen and postoperative infections were estimated using univariable and multivariable analysis. RESULTS: Rate of any postoperative infection was similar between the single- and multi-dose groups (19% vs. 16%, p=0.50). Rate of UTI was significantly higher in the single-dose compared to the multi-dose group (13% vs. 7%, p=0.03). On multivariable analysis, after controlling for vaginal route of surgery, the odds of UTI was not significantly different between groups (OR 0.59, 95% CI 0.27, 1.26). CONCLUSION: A single-dose antibiotic regimen is sufficient for prophylaxis against postoperative infections in women undergoing prolapse surgery with graft/mesh.
OBJECTIVE: To compare the risk of postoperative infections in women who receive single-dose versus multi-dose prophylactic antibiotic regimen during prolapse surgery with mesh/graft. STUDY DESIGN: Retrospective cohort study of 460 women who underwent prolapse surgery with mesh/graft. We compared women who received a single-dose prophylactic antibiotic regimen to those who received a multi-dose regimen. The primary outcome was the presence of any postoperative infection, defined as the presence of any of the following infections: urinary tract infection (UTI), fever, wound or trocar site infection, mesh infection or pelvic abscess. Associations between prophylactic antibiotic regimen and postoperative infections were estimated using univariable and multivariable analysis. RESULTS: Rate of any postoperative infection was similar between the single- and multi-dose groups (19% vs. 16%, p=0.50). Rate of UTI was significantly higher in the single-dose compared to the multi-dose group (13% vs. 7%, p=0.03). On multivariable analysis, after controlling for vaginal route of surgery, the odds of UTI was not significantly different between groups (OR 0.59, 95% CI 0.27, 1.26). CONCLUSION: A single-dose antibiotic regimen is sufficient for prophylaxis against postoperative infections in women undergoing prolapse surgery with graft/mesh.
Authors: Gary Sutkin; Marianna Alperin; Leslie Meyn; Harold C Wiesenfeld; Rennique Ellison; Halina M Zyczynski Journal: Int Urogynecol J Date: 2010-03-31 Impact factor: 2.894
Authors: Lieschen H Quiroz; Robert E Gutman; Stuart Shippey; Geoffery W Cundiff; Tatiana Sanses; Joan L Blomquist; Victoria L Handa Journal: Am J Obstet Gynecol Date: 2008-05 Impact factor: 8.661
Authors: Mia Swartz; Christina Ching; Bradley Gill; Jianbo Li; Raymond Rackley; Sandip Vasavada; Howard B Goldman Journal: Urology Date: 2010-03-17 Impact factor: 2.649
Authors: Reijo Hiltunen; Kari Nieminen; Teuvo Takala; Eila Heiskanen; Mauri Merikari; Kirsti Niemi; Pentti K Heinonen Journal: Obstet Gynecol Date: 2007-08 Impact factor: 7.661