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Literature DB >> 25116739

A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.

Abstract

Metal chelators masked with protecting groups for targeted release have the potential to conditionally modulate cellular metals. We report a new route to prepare cis-cinnamate protecting groups that enabled development of a prochelator with chemical stimulus response, fluorescent reporting and active compound release in a single structure.

Entities: Chemical Disease Species

Mesh：

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Year: 2014 PMID： 25116739 PMCID： PMC4154376 DOI： 10.1039/c4cc05076b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

14 in total

Review 1. Prodrug approaches to the improved delivery of peptide drugs.

Authors: W Wang; J Jiang; C E Ballard; B Wang
Journal: Curr Pharm Des Date: 1999-04 Impact factor: 3.116

2. Luminescent lanthanide complexes with analyte-triggered antenna formation.

Authors: Elias Pershagen; Johan Nordholm; K Eszter Borbas
Journal: J Am Chem Soc Date: 2012-02-29 Impact factor: 15.419

3. Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.

Authors: Qiong Xie; Xiaolin Wang; Xinghai Wang; Zhiqiang Jiang; Zhuibai Qiu
Journal: Bioorg Med Chem Lett Date: 2005-11-15 Impact factor: 2.823

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Authors: Aftab Ala; Ann P Walker; Keyoumars Ashkan; James S Dooley; Michael L Schilsky
Journal: Lancet Date: 2007-02-03 Impact factor: 79.321

5. Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.

Authors: Jody L Major Jourden; Kevin B Daniel; Seth M Cohen
Journal: Chem Commun (Camb) Date: 2011-06-16 Impact factor: 6.222

6. Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.

Authors: Jacek Zielonka; Adam Sikora; Micael Hardy; Joy Joseph; Brian P Dranka; Balaraman Kalyanaraman
Journal: Chem Res Toxicol Date: 2012-06-25 Impact factor: 3.739

7. The lactonization of ring-substituted coumarinic acids. Structural effects on the partitioning of tetrahedral intermediates in esterification.

Authors: R Hershfield; G L Schmir
Journal: J Am Chem Soc Date: 1973-10-31 Impact factor: 15.419

A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.

Review 1. Prodrug approaches to the improved delivery of peptide drugs.

2. Luminescent lanthanide complexes with analyte-triggered antenna formation.

3. Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.

Review 4. Wilson's disease.

5. Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.

6. Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.

7. The lactonization of ring-substituted coumarinic acids. Structural effects on the partitioning of tetrahedral intermediates in esterification.

8. Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major.

9. A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.

10. Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.

1. Stimulus-Responsive Prochelators for Manipulating Cellular Metals.

Review 2. Prodrug strategies for targeted therapy triggered by reactive oxygen species.

Review 3. Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond.

4. Visualization of endogenous and exogenous hydrogen peroxide using a lysosome-targetable fluorescent probe.