| Literature DB >> 16154745 |
Qiong Xie1, Xiaolin Wang, Xinghai Wang, Zhiqiang Jiang, Zhuibai Qiu.
Abstract
Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prodrug (3) showed a 4-fold increase in oral bioavailability over the parent drug meptazinol in rats.Entities:
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Year: 2005 PMID： 16154745 DOI： 10.1016/j.bmcl.2005.08.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823