Jari Rautiainen1,2,3, Mikko J Nissi3,4, Elli-Noora Salo5, Virpi Tiitu6, Mikko A J Finnilä7, Olli-Matti Aho8, Simo Saarakkala2,5,7, Petri Lehenkari8, Jutta Ellermann4, Miika T Nieminen1,5. 1. Department of Diagnostic Radiology, University of Oulu, Oulu, Finland. 2. Medical Research Center Oulu, University of Oulu, Oulu, Finland. 3. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland. 4. Center for Magnetic Resonance Research, Departments of Radiology and Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA. 5. Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. 6. Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland. 7. Department of Medical Technology, University of Oulu, Oulu, Finland. 8. Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland.
Abstract
PURPOSE: To evaluate the sensitivity of quantitative MRI techniques (T1 , T1,Gd , T2 , continous wave (CW) T1ρ dispersion, adiabatic T1ρ , adiabatic T2ρ , RAFF and inversion-prepared magnetization transfer (MT)) for assessment of human articular cartilage with varying degrees of natural degeneration. METHODS: Osteochondral samples (n = 14) were obtained from the tibial plateaus of patients undergoing total knee replacement. MRI of the specimens was performed at 9.4T and the relaxation time maps were evaluated in the cartilage zones. For reference, quantitative histology, OARSI grading and biomechanical measurements were performed and correlated with MRI findings. RESULTS: All MRI parameters, except T1,Gd , showed statistically significant differences in tangential and full-thickness regions of interest (ROIs) between early and advanced osteoarthritis (OA) groups, as classified by OARSI grading. CW-T1ρ showed significant dispersion in all ROIs and featured classical laminar structure of cartilage with spin-lock powers below 1000 Hz. Adiabatic T1ρ , T2ρ , CW-T1ρ, MT, and RAFF correlated strongly with OARSI grade and biomechanical parameters. CONCLUSION: MRI parameters were able to differentiate between early and advanced OA. Furthermore, rotating frame methods, namely adiabatic T1ρ , adiabatic T2ρ , CW-T1ρ , and RAFF, as well as MT experiment correlated strongly with biomechanical parameters and OARSI grade, suggesting high sensitivity of the parameters for cartilage degeneration. Magn Reson Med 74:249-259, 2015.
PURPOSE: To evaluate the sensitivity of quantitative MRI techniques (T1 , T1,Gd , T2 , continous wave (CW) T1ρ dispersion, adiabatic T1ρ , adiabatic T2ρ , RAFF and inversion-prepared magnetization transfer (MT)) for assessment of humanarticular cartilage with varying degrees of natural degeneration. METHODS: Osteochondral samples (n = 14) were obtained from the tibial plateaus of patients undergoing total knee replacement. MRI of the specimens was performed at 9.4T and the relaxation time maps were evaluated in the cartilage zones. For reference, quantitative histology, OARSI grading and biomechanical measurements were performed and correlated with MRI findings. RESULTS: All MRI parameters, except T1,Gd , showed statistically significant differences in tangential and full-thickness regions of interest (ROIs) between early and advanced osteoarthritis (OA) groups, as classified by OARSI grading. CW-T1ρ showed significant dispersion in all ROIs and featured classical laminar structure of cartilage with spin-lock powers below 1000 Hz. Adiabatic T1ρ , T2ρ , CW-T1ρ, MT, and RAFF correlated strongly with OARSI grade and biomechanical parameters. CONCLUSION: MRI parameters were able to differentiate between early and advanced OA. Furthermore, rotating frame methods, namely adiabatic T1ρ , adiabatic T2ρ , CW-T1ρ , and RAFF, as well as MT experiment correlated strongly with biomechanical parameters and OARSI grade, suggesting high sensitivity of the parameters for cartilage degeneration. Magn Reson Med 74:249-259, 2015.
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