OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method. DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology. RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed. CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.
OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method. DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology. RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed. CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.
Authors: Sarah Y McCoy; Kerry A Falgowski; Padma P Srinivasan; William R Thompson; Erica M Selva; Catherine B Kirn-Safran Journal: Bone Date: 2011-12-02 Impact factor: 4.398
Authors: Akihiro Nakamura; Y Raja Rampersaud; Anirudh Sharma; Stephen J Lewis; Brian Wu; Poulami Datta; Kala Sundararajan; Helal Endisha; Evgeny Rossomacha; Jason S Rockel; Igor Jurisica; Mohit Kapoor Journal: JCI Insight Date: 2016-08-04
Authors: Sevan R Oungoulian; Krista M Durney; Brian K Jones; Christopher S Ahmad; Clark T Hung; Gerard A Ateshian Journal: J Biomech Date: 2015-04-15 Impact factor: 2.712
Authors: Josephine R Coury; Ryan Nixon; Melinda Collins; John Schwartz; Nadeen O Chahine; Daniel A Grande Journal: Cartilage Date: 2018-11-28 Impact factor: 4.634