| Literature DB >> 25090637 |
Matthew D Green1, Abbygail A Foster1, Chad T Greco1, Raghunath Roy1, Rachel M Lehr1, Thomas H Epps1, Millicent O Sullivan1.
Abstract
Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to advance non-viral gene packaging.Entities:
Year: 2014 PMID: 25090637 PMCID: PMC4115287 DOI: 10.1039/C4PY00638K
Source DB: PubMed Journal: Polym Chem ISSN: 1759-9954 Impact factor: 5.582