| Literature DB >> 25090240 |
Bruce R Levin1, Jeniffer Concepción-Acevedo2, Klas I Udekwu3.
Abstract
We postulate that phenotypic resistance to antibiotics, persistence, is not an evolved (selected-for) character but rather like mutation, an inadvertent product of different kinds of errors and glitches. The rate of generation of these errors is augmented by exposure to these drugs. The genes that have been identified as contributing to the production of persisters are analogous to the so-called mutator genes; they modulate the rate at which these errors occur and/or are corrected. In theory, these phenotypically resistant bacteria can retard the rate of microbiological cure by antibiotic treatment.Entities:
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Year: 2014 PMID： 25090240 PMCID： PMC4253300 DOI： 10.1016/j.mib.2014.06.016
Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934