Literature DB >> 25082194

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

Sandra S McAllister1, Robert A Weinberg2.   

Abstract

Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.

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Year:  2014        PMID： 25082194      PMCID： PMC6220424          DOI： 10.1038/ncb3015

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  129 in total

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  340 in total

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Review 7.  Status and future directions in the management of pancreatic cancer: potential impact of nanotechnology.

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