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Literature DB >> 14601044

The IGF-1 receptor in cancer biology.

Renato Baserga¹, Francesca Peruzzi, Krysztof Reiss.

Abstract

The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy. Copyright 2003 Wiley-Liss, Inc.

Entities: Disease Gene

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Year: 2003 PMID： 14601044 DOI： 10.1002/ijc.11487

Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396

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Cited

193 in total

1. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.

Authors: Danielle B Ulanet; Dale L Ludwig; C Ronald Kahn; Douglas Hanahan
Journal: Proc Natl Acad Sci U S A Date: 2010-05-10 Impact factor: 11.205

2. Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R).

Authors: William Engen; Terrence E O'Brien; Brendan Kelly; Jacinda Do; Liezel Rillera; Lance K Stapleton; Jack F Youngren; Marc O Anderson
Journal: Bioorg Med Chem Date: 2010-06-25 Impact factor: 3.641

3. IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance.

Authors: Xueyan Zhang; Jiayuan Sun; Huimin Wang; Yuqing Lou; Yanwei Zhang; Huifang Sha; Jiuxian Feng; Baohui Han
Journal: Tumour Biol Date: 2013-08-29

Review 4. The dynamic organization of gene-regulatory machinery in nuclear microenvironments.

Authors: Sayyed K Zaidi; Daniel W Young; Je-Yong Choi; Jitesh Pratap; Amjad Javed; Martin Montecino; Janet L Stein; Andre J van Wijnen; Jane B Lian; Gary S Stein
Journal: EMBO Rep Date: 2005-02 Impact factor: 8.807

5. Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer.

Authors: Zhen-Jun Li; Xiao-Jiang Ying; Hong-Liang Chen; Ping-Jiang Ye; Zhi-Liang Chen; Gang Li; Hua-Feng Jiang; Jiang Liu; Shu-Zhen Zhou
Journal: World J Gastroenterol Date: 2013-11-21 Impact factor: 5.742

6. Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.

Authors: Sara A Flanigan; Todd M Pitts; Timothy P Newton; Gillian N Kulikowski; Aik Choon Tan; Martine C McManus; Anna Spreafico; Maria I Kachaeva; Heather M Selby; John J Tentler; S Gail Eckhardt; Stephen Leong
Journal: Clin Cancer Res Date: 2013-09-17 Impact factor: 12.531

The IGF-1 receptor in cancer biology.

1. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.

2. Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R).

3. IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance.

Review 4. The dynamic organization of gene-regulatory machinery in nuclear microenvironments.

5. Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer.

6. Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.

7. FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion.

Review 8. Tumor metabolism: new opportunities for cancer therapy.

Review 9. New advances in targeted gastric cancer treatment.

10. Growth of v-src-transformed cells in serum-free medium through the induction of growth factors.