Wen Xu1, Jing Sun1, Wenbo Wang2, Xiran Wang3, Yan Jiang1, Wei Huang4, Xin Zheng5, Qiuping Wang6, Zhiwei Ning7, Yu Pei8, Min Nie1, Mei Li1, Ou Wang1, Xiaoping Xing1, Wei Yu9, Qiang Lin9, Ling Xu10, Weibo Xia1. 1. Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China. 2. Department of Endocrinology, Peking University Shougang Hospital, Beijing, China. 3. Department of Cadre Unit, General Hospital of the second Artillery Force, Beijing, China. 4. Department of Endocrinology, BeiJing Haidian Hospital; Beijing, China. 5. Department of Endocrinology, China Rehabilitation Research Center, Beijing, China. 6. Department of Endocrinology, Beijing Liangxiang Hospital, Beijing, China. 7. Department of Endocrinology, Beijing Chaoyang Hospital, Beijing, China. 8. Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing, China. 9. Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China. 10. Department of Gynaecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Science; Beijing, China.
Abstract
OBJECTIVE: To determine if GC (group-specific component globulin) and CYP2R1 genetic variants have an association with serum 25-OHD3 levels, BMD or bone turnover markers in a population of Chinese postmenopausal women. DESIGN: We randomly selected 1494 postmenopausal women of the Han ethnic group from seven communities in Beijing. BMD was determined by dual energy X-ray absorptiometry; serum bone turnover markers and 25-OHD3 were measured by the automated Roche electrochemiluminescence system; genotypes of GC and CYP2R1 were detected by the TaqMan allelic discrimination assay. Multiple statistic methods were used to test the associations of SNP genotypes and vitamin D levels. RESULTS: In our sample, 89.6% women had vitamin D deficiency and another 9.8% had vitamin D insufficiency. The variants of rs2298849 (β=0.105, P<0.001) in GC were significantly associated with serum 25-OHD3 levels. Allele G of rs2298849 might be protective for serum 25-OHD3 level. Among the haplotypes of rs222020-rs2298849, CG (β=0.104, P=0.001) corresponded to increasing serum 25-OHD3 concentrations. CYP2R1 polymorphisms showed some significant association with serum β-CTX and P1NP levels. CONCLUSIONS: We found that GC variants had a significant association with serum 25-OHD3 levels among postmenopausal women of the Han ethnic group in Beijing, while CYP2R1 variants were not found to be significant.
OBJECTIVE: To determine if GC (group-specific component globulin) and CYP2R1 genetic variants have an association with serum 25-OHD3 levels, BMD or bone turnover markers in a population of Chinese postmenopausal women. DESIGN: We randomly selected 1494 postmenopausal women of the Han ethnic group from seven communities in Beijing. BMD was determined by dual energy X-ray absorptiometry; serum bone turnover markers and 25-OHD3 were measured by the automated Roche electrochemiluminescence system; genotypes of GC and CYP2R1 were detected by the TaqMan allelic discrimination assay. Multiple statistic methods were used to test the associations of SNP genotypes and vitamin D levels. RESULTS: In our sample, 89.6% women had vitamin D deficiency and another 9.8% had vitamin Dinsufficiency. The variants of rs2298849 (β=0.105, P<0.001) in GC were significantly associated with serum 25-OHD3 levels. Allele G of rs2298849 might be protective for serum 25-OHD3 level. Among the haplotypes of rs222020-rs2298849, CG (β=0.104, P=0.001) corresponded to increasing serum 25-OHD3 concentrations. CYP2R1 polymorphisms showed some significant association with serum β-CTX and P1NP levels. CONCLUSIONS: We found that GC variants had a significant association with serum 25-OHD3 levels among postmenopausal women of the Han ethnic group in Beijing, while CYP2R1 variants were not found to be significant.
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