Literature DB >> 17145786

Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.

S Radhika Prathalingham1, Shane R Wilkinson, David Horn, John M Kelly.   

Abstract

It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.

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Year:  2006        PMID： 17145786      PMCID： PMC1797777          DOI： 10.1128/AAC.01360-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Identification of a developmentally regulated iron superoxide dismutase of Trypanosoma brucei.

Authors:  M Kabiri; D Steverding
Journal:  Biochem J       Date:  2001-11-15       Impact factor: 3.857

Review 2.  Chemotherapy of Chagas' disease: status and new developments.

Authors:  Hugo Cerecetto; Mercedes González
Journal:  Curr Top Med Chem       Date:  2002-11       Impact factor: 3.295

Review 3.  Human African trypanosomiasis of the CNS: current issues and challenges.

Authors:  Peter G E Kennedy
Journal:  J Clin Invest       Date:  2004-02       Impact factor: 14.808

Review 4.  Chemotherapy of trypanosomiases and leishmaniasis.

Authors:  Simon L Croft; Michael P Barrett; Julio A Urbina
Journal:  Trends Parasitol       Date:  2005-09-08

Review 5.  The iron-containing superoxide dismutases of trypanosomatidae.

Authors:  Julio F Turrens; Joe M McCord
Journal:  Free Radic Biol Med       Date:  2005-12-19       Impact factor: 7.376

6.  Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi.

Authors:  R Docampo; A O Stoppani
Journal:  Arch Biochem Biophys       Date:  1979-10-01       Impact factor: 4.013

7.  Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations.

Authors:  Simone Garcia; Carolina O Ramos; Juliana F V Senra; Fabio Vilas-Boas; Maurício M Rodrigues; Antonio C Campos-de-Carvalho; Ricardo Ribeiro-Dos-Santos; Milena B P Soares
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

8.  J-binding protein increases the level and retention of the unusual base J in trypanosome DNA.

Authors:  Mike Cross; Rudo Kieft; Robert Sabatini; Anita Dirks-Mulder; Inês Chaves; Piet Borst
Journal:  Mol Microbiol       Date:  2002-10       Impact factor: 3.501

9.  Enzymatic reduction studies of nitroheterocycles.

Authors:  C Viodé; N Bettache; N Cenas; R L Krauth-Siegel; G Chauvière; N Bakalara; J Périé
Journal:  Biochem Pharmacol       Date:  1999-03-01       Impact factor: 5.858

Review 10.  The trypanosomiases.

Authors:  Michael P Barrett; Richard J S Burchmore; August Stich; Julio O Lazzari; Alberto Carlos Frasch; Juan José Cazzulo; Sanjeev Krishna
Journal:  Lancet       Date:  2003-11-01       Impact factor: 79.321
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  16 in total

1.  Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.

Authors:  Shanshan He; Alex Dayton; Periannan Kuppusamy; Karl A Werbovetz; Mark E Drew
Journal:  Antimicrob Agents Chemother       Date:  2012-02-06       Impact factor: 5.191

2.  Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics.

Authors:  Eduardo de Figueiredo Peloso; Simone Cespedes Vitor; Luis Henrique Gonzaga Ribeiro; María Dolores Piñeyro; Carlos Robello; Fernanda Ramos Gadelha
Journal:  J Bioenerg Biomembr       Date:  2011-07-06       Impact factor: 2.945

3.  Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.

Authors:  Belinda S Hall; Shane R Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  2011-10-28       Impact factor: 5.191

Review 4.  Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease.

Authors:  Lucía Piacenza; Gonzalo Peluffo; María Noel Alvarez; Alejandra Martínez; Rafael Radi
Journal:  Antioxid Redox Signal       Date:  2012-05-21       Impact factor: 8.401

5.  Leishmania infantum isolates exhibit high infectivity and reduced susceptibility to amphotericin B.

Authors:  Paula Faral-Tello; Gonzalo Greif; Dinora Satragno; Yester Basmadjián; Carlos Robello
Journal:  RSC Med Chem       Date:  2020-07-06

6.  Evaluating 5-nitrofurans as trypanocidal agents.

Authors:  Christopher Bot; Belinda S Hall; Guzmán Alvarez; Rossanna Di Maio; Mercedes González; Hugo Cerecetto; Shane R Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  2013-01-18       Impact factor: 5.191

7.  A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.

Authors:  Shane R Wilkinson; Martin C Taylor; David Horn; John M Kelly; Ian Cheeseman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-26       Impact factor: 11.205

8.  The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.

Authors:  Flora J Logan; Martin C Taylor; Shane R Wilkinson; Harparkash Kaur; John M Kelly
Journal:  Biochem J       Date:  2007-11-01       Impact factor: 3.857

9.  Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.

Authors:  Belinda S Hall; Christopher Bot; Shane R Wilkinson
Journal:  J Biol Chem       Date:  2011-02-23       Impact factor: 5.157

10.  The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi.

Authors:  Marcia Cristina Paes; Daniela Cosentino-Gomes; Cíntia Fernandes de Souza; Natália Pereira de Almeida Nogueira; José Roberto Meyer-Fernandes
Journal:  J Parasitol Res       Date:  2011-10-09
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