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Literature DB >> 25078796

Efficient synthesis of functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] via one-pot three-component reaction.

Chao Wang¹, Yan-Hong Jiang, Chao-Guo Yan.

Abstract

Diverse functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] were efficiently synthesized by the three-component reaction of 3-arylamino-1-methyl-H-pyrrole-2,5-dione, isatins and malononitrile (ethyl cyanoacetate) in ethanol in the presence of triethylamine. This reaction not only provided a convenient synthetic method for the construction of a versatile spirooxindole system, but also access to reactive β-enaminone and its derivatives for organic and medical chemistry.

Entities: Chemical

Mesh：

Substances：
Spiro Compounds

Year: 2014 PMID： 25078796 DOI： 10.1007/s11030-014-9540-8

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

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References

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Authors: Jing Sun; Yan Sun; Er-Yan Xia; Chao-Guo Yan
Journal: ACS Comb Sci Date: 2011-06-13 Impact factor: 3.784

Efficient synthesis of functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] via one-pot three-component reaction.

1. Spatial and seasonal toxicity in a stormwater management facility: evidence obtained by adapting an integrated sediment quality assessment approach.

2. Cu(OAc)2/TFA-promoted formal [3 + 3] cycloaddition/oxidation of enamines and enones for synthesis of multisubstituted aromatic amines.

3. Three-component domino reactions for selective formation of indeno[1,2-b]indole derivatives.

4. Synthesis of functionalized 2-aminohydropyridines and 2-pyridinones via domino reactions of arylamines, methyl propiolate, aromatic aldehydes, and substituted acetonitriles.

5. Facile one-pot synthesis of 2,3,5-substituted 1,2,4-oxadiazolines from nitriles in aqueous solution.

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