Literature DB >> 22724429

Cu(OAc)2/TFA-promoted formal [3 + 3] cycloaddition/oxidation of enamines and enones for synthesis of multisubstituted aromatic amines.

Liang Li1, Mi-Na Zhao, Zhi-Hui Ren, Jian-Li Li, Zheng-Hui Guan.   

Abstract

New strategies for the oxidative cycloaddition of enones with enamines are developed. These cycloaddition reactions directly afford substituted aromatic amines, which are important in organic chemistry, in moderate to good yield. Cu(OAc)(2)/TFA is shown to be essential to achieve high reaction efficiency.

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Year:  2012        PMID： 22724429     DOI： 10.1021/ol3014733

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Efficient synthesis of functionalized spiro[indoline-3,4'-pyrrolo[3,4-b]pyridines] via one-pot three-component reaction.

Authors:  Chao Wang; Yan-Hong Jiang; Chao-Guo Yan
Journal:  Mol Divers       Date:  2014-07-31       Impact factor: 2.943

2.  The [3 + 3]-cycloaddition alternative for heterocycle syntheses: catalytically generated metalloenolcarbenes as dipolar adducts.

Authors:  Xinfang Xu; Michael P Doyle
Journal:  Acc Chem Res       Date:  2014-03-20       Impact factor: 22.384

3.  De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.

Authors:  Matthew R Tatton; Iain Simpson; Timothy J Donohoe
Journal:  Org Lett       Date:  2014-03-19       Impact factor: 6.005

4.  Branch-Selective Alkene Hydroarylation by Cooperative Destabilization: Iridium-Catalyzed ortho-Alkylation of Acetanilides.

Authors:  Giacomo E M Crisenza; Olga O Sokolova; John F Bower
Journal:  Angew Chem Int Ed Engl       Date:  2015-10-22       Impact factor: 15.336
  4 in total

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