Literature DB >> 25077135

Projections of preventable risks for cardiovascular disease in Canada to 2021: a microsimulation modelling approach.

Douglas G Manuel1, Meltem Tuna2, Deirdre Hennessy3, Carol Bennett4, Anya Okhmatovskaia5, Philippe Finès6, Peter Tanuseputro7, Jack V Tu8, William Flanagan6.   

Abstract

BACKGROUND: Reductions in preventable risks associated with cardiovascular disease have contributed to a steady decrease in its incidence over the past 50 years in most developed countries. However, it is unclear whether this trend will continue. Our objective was to examine future risk by projecting trends in preventable risk factors in Canada to 2021.
METHODS: We created a population-based microsimulation model using national data on births, deaths and migration; socioeconomic data; cardiovascular disease risk factors; and algorithms for changes in these risk factors (based on sociodemographic characteristics and previous cardiovascular disease risk). An initial population of 22.5 million people, representing the Canadian adult population in 2001, had 13 characteristics including the risk factors used in clinical risk prediction. There were 6.1 million potential exposure profiles for each person each year. Outcome measures included annual prevalence of risk factors (smoking, obesity, diabetes, hypertension and lipid levels) and of co-occurring risks.
RESULTS: From 2003 to 2009, the projected risks of cardiovascular disease based on the microsimulation model closely approximated those based on national surveys. Except for obesity and diabetes, all risk factors were projected to decrease through to 2021. The largest projected decreases were for the prevalence of smoking (from 25.7% in 2001 to 17.7% in 2021) and uncontrolled hypertension (from 16.1% to 10.8%). Between 2015 and 2017, obesity was projected to surpass smoking as the most prevalent risk factor.
INTERPRETATION: Risks of cardiovascular disease are projected to decrease modestly in Canada, leading to a likely continuing decline in its incidence.

Entities:  

Year:  2014        PMID: 25077135      PMCID: PMC4089435          DOI: 10.9778/cmajo.2012-0015

Source DB:  PubMed          Journal:  CMAJ Open        ISSN: 2291-0026


  15 in total

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Authors:  S Jay Olshansky; Douglas J Passaro; Ronald C Hershow; Jennifer Layden; Bruce A Carnes; Jacob Brody; Leonard Hayflick; Robert N Butler; David B Allison; David S Ludwig
Journal:  N Engl J Med       Date:  2005-03-17       Impact factor: 91.245

2.  14-year diabetes incidence: the role of socio-economic status.

Authors:  Nancy A Ross; Heather Gilmour; Kaberi Dasgupta
Journal:  Health Rep       Date:  2010-09       Impact factor: 4.796

3.  IMPACT: a generic tool for modelling and simulating public health policy.

Authors:  J D Ainsworth; E Carruthers; P Couch; N Green; M O'Flaherty; M Sperrin; R Williams; Z Asghar; S Capewell; I E Buchan
Journal:  Methods Inf Med       Date:  2011-09-14       Impact factor: 2.176

4.  Changes in the rates of awareness, treatment and control of hypertension in Canada over the past two decades.

Authors:  Finlay A McAlister; Kathryn Wilkins; Michel Joffres; Frans H H Leenen; George Fodor; Marianne Gee; Mark S Tremblay; Robin Walker; Helen Johansen; Norm Campbell
Journal:  CMAJ       Date:  2011-05-16       Impact factor: 8.262

5.  POHEM--a framework for understanding and modelling the health of human populations.

Authors:  M C Wolfson
Journal:  World Health Stat Q       Date:  1994

6.  Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005.

Authors:  Harindra C Wijeysundera; Márcio Machado; Farah Farahati; Xuesong Wang; William Witteman; Gabrielle van der Velde; Jack V Tu; Douglas S Lee; Shaun G Goodman; Robert Petrella; Martin O'Flaherty; Murray Krahn; Simon Capewell
Journal:  JAMA       Date:  2010-05-12       Impact factor: 56.272

7.  Trends in weight change among Canadian adults.

Authors:  Heather M Orpana; Mark S Tremblay; Philippe Finès
Journal:  Health Rep       Date:  2007-05       Impact factor: 4.796

8.  Overweight and obesity as determinants of cardiovascular risk: the Framingham experience.

Authors:  Peter W F Wilson; Ralph B D'Agostino; Lisa Sullivan; Helen Parise; William B Kannel
Journal:  Arch Intern Med       Date:  2002-09-09

Review 9.  Validation of population-based disease simulation models: a review of concepts and methods.

Authors:  Jacek A Kopec; Philippe Finès; Douglas G Manuel; David L Buckeridge; William M Flanagan; Jillian Oderkirk; Michal Abrahamowicz; Samuel Harper; Behnam Sharif; Anya Okhmatovskaia; Eric C Sayre; M Mushfiqur Rahman; Michael C Wolfson
Journal:  BMC Public Health       Date:  2010-11-18       Impact factor: 3.295

10.  A population-based risk algorithm for the development of diabetes: development and validation of the Diabetes Population Risk Tool (DPoRT).

Authors:  Laura C Rosella; Douglas G Manuel; Charles Burchill; Thérèse A Stukel
Journal:  J Epidemiol Community Health       Date:  2010-06-01       Impact factor: 3.710

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  16 in total

1.  Validation of a Cardiovascular Disease Policy Microsimulation Model Using Both Survival and Receiver Operating Characteristic Curves.

Authors:  Ankur Pandya; Stephen Sy; Sylvia Cho; Sartaj Alam; Milton C Weinstein; Thomas A Gaziano
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2.  The risk of addressing only risks.

Authors:  Garry Egger; John Dixon
Journal:  CMAJ       Date:  2014-05-20       Impact factor: 8.262

3.  Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts.

Authors:  Nana Amankwah; Ruth Ann Marrie; Christina Bancej; Rochelle Garner; Douglas G Manuel; Ron Wall; Philippe Finès; Julie Bernier; Karen Tu; Kim Reimer
Journal:  Health Promot Chronic Dis Prev Can       Date:  2017-02       Impact factor: 3.240

4.  Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey.

Authors:  Minh T Do; Vicky C Chang; Michelle A Mendez; Margaret de Groh
Journal:  Health Promot Chronic Dis Prev Can       Date:  2017-12       Impact factor: 3.240

5.  Cerebral palsy in Canada, 2011-2031: results of a microsimulation modelling study of epidemiological and cost impacts.

Authors:  Nana Amankwah; Maryam Oskoui; Rochelle Garner; Christina Bancej; Douglas G Manuel; Ron Wall; Philippe Finès; Julie Bernier; Karen Tu; Kim Reimer
Journal:  Health Promot Chronic Dis Prev Can       Date:  2020-02       Impact factor: 3.240

6.  Effects of Reductions in Body Mass Index on the Future Osteoarthritis Burden in Canada: A Population-Based Microsimulation Study.

Authors:  Jacek A Kopec; Eric C Sayre; Philippe Fines; William M Flanagan; Claude Nadeau; Anya Okhmatovskaia; Michael C Wolfson
Journal:  Arthritis Care Res (Hoboken)       Date:  2016-08       Impact factor: 4.794

7.  Alzheimer's and other dementias in Canada, 2011 to 2031: a microsimulation Population Health Modeling (POHEM) study of projected prevalence, health burden, health services, and caregiving use.

Authors:  Douglas G Manuel; Rochelle Garner; Philippe Finès; Christina Bancej; William Flanagan; Karen Tu; Kim Reimer; Larry W Chambers; Julie Bernier
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Review 8.  Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity.

Authors:  Kelsey H Collins; Walter Herzog; Graham Z MacDonald; Raylene A Reimer; Jaqueline L Rios; Ian C Smith; Ronald F Zernicke; David A Hart
Journal:  Front Physiol       Date:  2018-02-23       Impact factor: 4.566

9.  The Population Health Model (POHEM): an overview of rationale, methods and applications.

Authors:  Deirdre A Hennessy; William M Flanagan; Peter Tanuseputro; Carol Bennett; Meltem Tuna; Jacek Kopec; Michael C Wolfson; Douglas G Manuel
Journal:  Popul Health Metr       Date:  2015-09-03

10.  Six-year time-trend analysis of dyslipidemia among adults in Newfoundland and Labrador: findings from the laboratory information system between 2009 and 2014.

Authors:  Pardis Pedram; Erfan Aref-Eshghi; Hensley H Mariathas; Oliver Hurley; Marshall Godwin; Pauline Duke; Masoud Mahdavian; Shabnam Asghari
Journal:  Lipids Health Dis       Date:  2018-05-02       Impact factor: 3.876

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