| Literature DB >> 25072605 |
Wouter Van Hecke1, Guneet Kaur2, Heleen De Wever3.
Abstract
The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR) in whole-cell biotechnology over the last 10years. It summarizes various ISPR-integrated fermentation processes for the production of a wide spectrum of bio-based products. A critical assessment of the performance of various ISPR concepts with respect to the degree of product enrichment, improved productivity, reduced process flows and increased yields is provided. Requirements to allow a successful industrial implementation of ISPR are also discussed. Finally, supporting technologies such as online monitoring, mathematical modeling and use of recombinant microorganisms with ISPR are presented.Keywords: ISPR-coupled whole-cell bioprocess; In-situ product recovery (ISPR); Microbial biotransformations
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Year: 2014 PMID: 25072605 DOI: 10.1016/j.biotechadv.2014.07.003
Source DB: PubMed Journal: Biotechnol Adv ISSN: 0734-9750 Impact factor: 14.227