Michael H Gold1, Brian Berman, Matteo Tretti Clementoni, Gerd G Gauglitz, Foad Nahai, Crystal Murcia. 1. *Gold Skin Care Center and Tennessee Clinical Research Center, Nashville, Tennessee; †Center for Clinical and Cosmetic Research, Aventura, Florida; ‡Department of Laser and Surgery, Istituto Dermatologico Europeo, Milano, Italy; §Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany; ‖Paces Plastic Surgery, Atlanta, Georgia; ¶Inkwell Medical Communications, Novelty, Ohio.
Abstract
BACKGROUND: There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice. OBJECTIVE: To review available data on methods for preventing and treating cutaneous scarring. MATERIALS AND METHODS: Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management. RESULTS: One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment. CONCLUSION: Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.
BACKGROUND: There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice. OBJECTIVE: To review available data on methods for preventing and treating cutaneous scarring. MATERIALS AND METHODS: Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management. RESULTS: One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment. CONCLUSION: Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.
Authors: Alana Kurtti; Julie K Nguyen; Jeremy Weedon; Andrew Mamalis; Yi Lai; Natasha Masub; Amaris Geisler; Daniel M Siegel; Jared R Jagdeo Journal: J Biophotonics Date: 2021-05-04 Impact factor: 3.207
Authors: Sara Tanini; Sara Calabrese; Alessandra D Fisher; Mario Maggi; Giulia Lo Russo Journal: Aesthetic Plast Surg Date: 2020-03-20 Impact factor: 2.326