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Literature DB >> 2506531

A novel germ-line JK transcript starting immediately upstream of JK1.

Abstract

Germ-line transcripts of the immunoglobulin (Ig) and T cell receptor loci are thought to be involved in the control of V gene rearrangement by rendering these loci accessible to the recombinases. We have analyzed the transcriptional activity of germ-line K alleles in two bone marrow-derived Abelson-murine leukemia virus transformed pre-B cells: 300-19, a null cell line, and P8 a mu-producing line. We found a novel germ-line JK transcript starting immediately upstream of JK1 and spliced to CK. The potential role of this transcript in the opening of the Ig K locus as well as in the ordered usage of JK segments is discussed.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2506531 PMCID： PMC318414 DOI： 10.1093/nar/17.17.6809

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

35 in total

1. B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment.

Authors: D Weaver; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

2. Multiple nuclear factors interact with the immunoglobulin enhancer sequences.

Authors: R Sen; D Baltimore
Journal: Cell Date: 1986-08-29 Impact factor: 41.582

3. Transcription of the unrearranged mouse C kappa locus: sequence of the initiation region and comparison of activity with a rearranged V kappa-C kappa gene.

Authors: B G Van Ness; M Weigert; C Coleclough; E L Mather; D E Kelley; R P Perry
Journal: Cell Date: 1981-12 Impact factor: 41.582

4. Accurate 5' splice-site selection in mouse kappa immunoglobulin light chain premessenger RNAs is not cell-type-specific.

Authors: D H Kedes; J A Steitz
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

5. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors: D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971

6. A simple and very efficient method for generating cDNA libraries.

Authors: U Gubler; B J Hoffman
Journal: Gene Date: 1983-11 Impact factor: 3.688

7. Structure of a nuclease-sensitive region inside the immunoglobin kappa gene: evidence for a role in gene regulation.

Authors: T G Parslow; D K Granner
Journal: Nucleic Acids Res Date: 1983-07-25 Impact factor: 16.971

8. Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylation status.

Authors: K J Nelson; E L Mather; R P Perry
Journal: Nucleic Acids Res Date: 1984-02-24 Impact factor: 16.971

9. Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

Authors: D L Wood; C Coleclough
Journal: Proc Natl Acad Sci U S A Date: 1984-08 Impact factor: 11.205

10. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.

Authors: M Schwab; K Alitalo; H E Varmus; J M Bishop; D George
Journal: Nature Date: 1983 Jun 9-15 Impact factor: 49.962

11 in total

1. Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.

Authors: D J Martin; B G van Ness
Journal: Mol Cell Biol Date: 1990-05 Impact factor: 4.272

2. Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

Authors: Rupesh H Amin; Dragana Cado; Hector Nolla; Dan Huang; Susan A Shinton; Yan Zhou; Richard R Hardy; Mark S Schlissel
Journal: Proc Natl Acad Sci U S A Date: 2008-12-30 Impact factor: 11.205

3. mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end.

Authors: G A Neale; G R Kitchingman
Journal: Nucleic Acids Res Date: 1991-05-11 Impact factor: 16.971

4. Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line.

Authors: A M Shapiro; M S Schlissel; D Baltimore; A L DeFranco
Journal: Mol Cell Biol Date: 1993-09 Impact factor: 4.272

5. Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival.

Authors: A Strasser; A G Elefanty; A W Harris; S Cory
Journal: EMBO J Date: 1996-08-01 Impact factor: 11.598