Arpita Basu1, Alicia J Jenkins2,3, Julie A Stoner4, Suzanne R Thorpe5, Richard L Klein6,7, Maria F Lopes-Virella6,7, W Timothy Garvey8, Timothy J Lyons3,9. 1. Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma. 2. University of Sydney, NHMRC Clinical Trials Centre, Camperdown, Sydney, NSW, Australia. 3. Centre for Experimental Medicine, Queen's University of Belfast, N. Ireland, UK. 4. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. 5. Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina. 6. Division of Endocrinology, Medical University of South Carolina, Charleston, South Carolina. 7. The Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina. 8. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama. 9. Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Abstract
OBJECTIVE: Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and internal carotid IMT over a 6-year period in type 1 diabetes. RESEARCH DESIGN AND METHODS: tHcy levels were measured once, in plasma obtained in 1997-1999 from patients (n = 599) in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT). Common and internal carotid IMT were determined twice, in EDIC "Year 6" (1998-2000) and "Year 12" (2004-2006), using B-mode ultra-sonography. RESULTS: After adjustment, plasma tHcy [median (interquartile range): 6.2 (5.1, 7.5) μmol/L] was significantly correlated with age, diastolic blood pressure, renal dysfunction, and smoking (all p < 0.05). In an unadjusted model only, increasing quartiles of tHcy correlated with common and internal carotid IMT, again at both EDIC time-points (p < 0.01). However, multivariate logistic regression revealed no significant associations between increasing quartiles of tHcy and the 6-year change in common and internal carotid IMT (highest vs. lowest quintile) when adjusted for conventional risk factors. CONCLUSIONS: In a type 1 diabetes cohort from the EDIC study, plasma tHcy measured in samples drawn in 1997-1999 was associated with measures of common and internal carotid IMT measured both one and seven years later, but not with IMT progression between the two time-points. The data do not support routine measurement of tHcy in people with Type 1 diabetes.
OBJECTIVE: Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabeticpatients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and internal carotid IMT over a 6-year period in type 1 diabetes. RESEARCH DESIGN AND METHODS: tHcy levels were measured once, in plasma obtained in 1997-1999 from patients (n = 599) in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT). Common and internal carotid IMT were determined twice, in EDIC "Year 6" (1998-2000) and "Year 12" (2004-2006), using B-mode ultra-sonography. RESULTS: After adjustment, plasma tHcy [median (interquartile range): 6.2 (5.1, 7.5) μmol/L] was significantly correlated with age, diastolic blood pressure, renal dysfunction, and smoking (all p < 0.05). In an unadjusted model only, increasing quartiles of tHcy correlated with common and internal carotid IMT, again at both EDIC time-points (p < 0.01). However, multivariate logistic regression revealed no significant associations between increasing quartiles of tHcy and the 6-year change in common and internal carotid IMT (highest vs. lowest quintile) when adjusted for conventional risk factors. CONCLUSIONS: In a type 1 diabetes cohort from the EDIC study, plasma tHcy measured in samples drawn in 1997-1999 was associated with measures of common and internal carotid IMT measured both one and seven years later, but not with IMT progression between the two time-points. The data do not support routine measurement of tHcy in people with Type 1 diabetes.
Authors: E K Hoogeveen; P J Kostense; C Jakobs; J M Dekker; G Nijpels; R J Heine; L M Bouter; C D Stehouwer Journal: Circulation Date: 2000-04-04 Impact factor: 29.690
Authors: M A Hofmann; E Lalla; Y Lu; M R Gleason; B M Wolf; N Tanji; L J Ferran; B Kohl; V Rao; W Kisiel; D M Stern; A M Schmidt Journal: J Clin Invest Date: 2001-03 Impact factor: 14.808
Authors: Manjula Kurella Tamura; Dawei Xie; Kristine Yaffe; Debbie L Cohen; Valerie Teal; Scott E Kasner; Steven R Messé; Ashwini R Sehgal; John Kusek; Karen B DeSalvo; Denise Cornish-Zirker; Janet Cohan; Stephen L Seliger; Glenn M Chertow; Alan S Go Journal: Clin J Am Soc Nephrol Date: 2010-10-07 Impact factor: 8.237
Authors: Prabath W B Nanayakkara; Coen van Guldener; Piet M ter Wee; Peter G Scheffer; Frans J van Ittersum; Jos W Twisk; Tom Teerlink; Wim van Dorp; Coen D A Stehouwer Journal: Arch Intern Med Date: 2007-06-25
Authors: Ghufran S Babar; Hanaa Zidan; Michael E Widlansky; Emon Das; Raymond G Hoffmann; Marwan Daoud; Ramin Alemzadeh Journal: Diabetes Care Date: 2011-02-02 Impact factor: 19.112