Kuankuan Huang1, Zhixiang Zhang1, Shan Huang1, Yanwen Jia2, Min Zhang3, Wenwei Yun4. 1. Department of Neurology, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, No.29, Xinglong Lane, Tianning District, Changzhou, 213004, Jiangsu, China. 2. Ophthalmology Department of Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, No.29, Xinglong Lane, Tianning District, 213004, Changzhou, Jiangsu, China. 3. Department of Neurology, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, No.29, Xinglong Lane, Tianning District, Changzhou, 213004, Jiangsu, China. zhangjueming11@163.com. 4. Department of Neurology, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, No.29, Xinglong Lane, Tianning District, Changzhou, 213004, Jiangsu, China. xjyww@sina.com.
Abstract
BACKGROUND: This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. METHODS: Hypertensive patients were retrospectively enrolled in this study. According to plasma homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension groups. The diameter of retinal vessels and retinopathy were evaluated by retinal fundus photography. The differences of retinal vessel abnormalities between H-type hypertension and isolated hypertension were investigated by univariate and multivariate regression. RESULTS: A total of 191 hypertensive patients were included, of which 86 were with isolated hypertension and 105 with H-type hypertension. The H-type hypertension group had a higher ratio of retinopathy(P = 0.004) and higher degree of retinal arteriosclerosis (P = 0.005) than the isolated hypertension group. CRAE (107.47 ± 13.99µ m vs. 113.49 ± 11.72µ m, P = 0.002) and AVR (0.55 ± 0.06 vs. 0.58 ± 0.06, P = 0.001) were smaller in H-type hypertension group than those in isolated hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension was an independent risk factor of retinopathy (OR, 2.259; 95%CI, 1.165-4.378; P = 0.016), CRAE (β=-5.669; 95%CI, -9.452--1.886; P = 0.004), and AVR (β=-0.023; 95%CI, -0.039--0.007; P = 0.005). CONCLUSIONS: H-type hypertension is closely related to more retinal vessel abnormalities than isolated hypertension. Controlling H-type hypertension may reduce the risk of small vascular damage.
BACKGROUND: This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. METHODS:Hypertensivepatients were retrospectively enrolled in this study. According to plasma homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension groups. The diameter of retinal vessels and retinopathy were evaluated by retinal fundus photography. The differences of retinal vessel abnormalities between H-type hypertension and isolated hypertension were investigated by univariate and multivariate regression. RESULTS: A total of 191 hypertensivepatients were included, of which 86 were with isolated hypertension and 105 with H-type hypertension. The H-type hypertension group had a higher ratio of retinopathy(P = 0.004) and higher degree of retinal arteriosclerosis (P = 0.005) than the isolated hypertension group. CRAE (107.47 ± 13.99µ m vs. 113.49 ± 11.72µ m, P = 0.002) and AVR (0.55 ± 0.06 vs. 0.58 ± 0.06, P = 0.001) were smaller in H-type hypertension group than those in isolated hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension was an independent risk factor of retinopathy (OR, 2.259; 95%CI, 1.165-4.378; P = 0.016), CRAE (β=-5.669; 95%CI, -9.452--1.886; P = 0.004), and AVR (β=-0.023; 95%CI, -0.039--0.007; P = 0.005). CONCLUSIONS:H-type hypertension is closely related to more retinal vessel abnormalities than isolated hypertension. Controlling H-type hypertension may reduce the risk of small vascular damage.
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