Mandeep Singh1, Yi Ding2, Li-Ying Zhang3, Dong Song4, Yun Gong5, Sylvia Adams6, Dara S Ross3, Jin-Hua Wang6, Shruti Grover7, Dinesh Chandra Doval7, Charles Shao8, Zi-Li He9, Victor Chang10, Warren W Chin10, Fang-Ming Deng2, Baljit Singh2, David Zhang11, Ru-Liang Xu12, Peng Lee13. 1. Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA ; Rajiv Gandhi Cancer Institute & Research Centre Delhi, India. 2. Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA. 3. Department of Pathology, Memorial Sloan Kettering Cancer Center New York, NY, USA. 4. Department of Breast Surgery, The First Hospital of Jilin University China. 5. Department of Pathology, UT MD Anderson Cancer Center Houston, TX, USA. 6. NYU Cancer Institute New York, NY, USA. 7. Rajiv Gandhi Cancer Institute & Research Centre Delhi, India. 8. State University of New York-Downstate Medical Center Brooklyn, NY, USA. 9. Association of Chinese American Physicians Flushing, NY, USA. 10. Chinese American Medical Society New York, NY, USA. 11. Association of Chinese American Physicians Flushing, NY, USA ; Department of Pathology, Mount Sinai School of Medicine New York, NY, USA. 12. Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA ; Association of Chinese American Physicians Flushing, NY, USA. 13. Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine New York, NY, USA ; NYU Cancer Institute New York, NY, USA ; Association of Chinese American Physicians Flushing, NY, USA.
Abstract
BACKGROUND: Racial disparities among breast cancer (BCa) patients are known but not well studied in early-onset BCa. We analyzed molecular subtypes in early-onset BCa across five major races. METHODS: A total of 2120 cases were included from non-Hispanic White (NHW), African American (AA) and Hispanic, Chinese and Indian. Based on ER, PR and HER-2 status, BCa was classified into 4 intrinsic subtypes as Luminal A, Luminal B, HER2/neu overexpression and Triple negative BCa (TNBC) subtypes. Data was stratified according to race and age as younger/early-onset group (40-years and younger) and older group (50-years and older). RESULTS: In early-onset BCa, incidence of TNBC was significantly higher (p = 0.0369) in Indian women followed by AA, Hispanic, NHW and Chinese women. Incidence of Her2 over-expression subtype also was highest in Indian women, followed by Hispanic, Chinese, AA and NHW women. In contrast, Luminal B subtype was most significantly higher in AA women (p = 0.0000) followed by NHW (p = 0.0002), Chinese (p = 0.0003), Hispanic (0.0128) and Indian (p = 0.0468) women. Luminal A subtype was most significantly reduced in Indian women (p = 0.0113) followed by Hispanic, AA, NHW and Chinese women. These results were based on statistical analysis with the mean of older group populations. CONCLUSIONS: These results show significant disparities in receptor subtypes across races. This study will contribute in developing optimal clinical trial protocols and personalized management strategies for early-onset BCa patients.
BACKGROUND: Racial disparities among breast cancer (BCa) patients are known but not well studied in early-onset BCa. We analyzed molecular subtypes in early-onset BCa across five major races. METHODS: A total of 2120 cases were included from non-Hispanic White (NHW), African American (AA) and Hispanic, Chinese and Indian. Based on ER, PR and HER-2 status, BCa was classified into 4 intrinsic subtypes as Luminal A, Luminal B, HER2/neu overexpression and Triple negative BCa (TNBC) subtypes. Data was stratified according to race and age as younger/early-onset group (40-years and younger) and older group (50-years and older). RESULTS: In early-onset BCa, incidence of TNBC was significantly higher (p = 0.0369) in Indian women followed by AA, Hispanic, NHW and Chinese women. Incidence of Her2 over-expression subtype also was highest in Indian women, followed by Hispanic, Chinese, AA and NHW women. In contrast, Luminal B subtype was most significantly higher in AA women (p = 0.0000) followed by NHW (p = 0.0002), Chinese (p = 0.0003), Hispanic (0.0128) and Indian (p = 0.0468) women. Luminal A subtype was most significantly reduced in Indian women (p = 0.0113) followed by Hispanic, AA, NHW and Chinese women. These results were based on statistical analysis with the mean of older group populations. CONCLUSIONS: These results show significant disparities in receptor subtypes across races. This study will contribute in developing optimal clinical trial protocols and personalized management strategies for early-onset BCa patients.
Entities:
Keywords:
Breast cancer subtypes; global; races; receptor; risk
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