Literature DB >> 25040385

Genomic research with the newly dead: a crossroads for ethics and policy.

Rebecca L Walker1, Eric T Juengst, Warren Whipple, Arlene M Davis.   

Abstract

Recent advances in next generation sequencing along with high hopes for genomic medicine have inspired interest in genomic research with the newly dead. However, applicable law does not adequately determine ethical or policy responses to such research. In this paper we propose that such research stands at a crossroads between other more established biomedical clinical and research practices. In addressing the ethical and policy issues raised by a particular research project within our institution comparatively with these other practices, we illustrate the moral significance of paying careful heed to where one looks for guidance in responding to ethical questions raised by a novel endeavor.
© 2014 American Society of Law, Medicine & Ethics, Inc.

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Year:  2014        PMID: 25040385      PMCID: PMC4378691          DOI: 10.1111/jlme.12137

Source DB:  PubMed          Journal:  J Law Med Ethics        ISSN: 1073-1105            Impact factor:   1.718


  21 in total

1.  Taking DNA from the dead.

Authors:  Amy L McGuire; Mary A Majumder; Scott D Halpern; J S Swindell; Laura V Yaeger; Richard A Gibbs; Thomas M Wheeler
Journal:  Nat Rev Genet       Date:  2010-03-23       Impact factor: 53.242

2.  Genetics. No longer de-identified.

Authors:  Amy L McGuire; Richard A Gibbs
Journal:  Science       Date:  2006-04-21       Impact factor: 47.728

3.  The poor, the Black, and the marginalized as the source of cadavers in United States anatomical education.

Authors:  Edward C Halperin
Journal:  Clin Anat       Date:  2007-07       Impact factor: 2.414

Review 4.  The uneasy ethical and legal underpinnings of large-scale genomic biobanks.

Authors:  Henry T Greely
Journal:  Annu Rev Genomics Hum Genet       Date:  2007       Impact factor: 8.929

Review 5.  Should donors be allowed to give broad consent to future biobank research?

Authors:  Mats G Hansson; Joakim Dillner; Claus R Bartram; Joyce A Carlson; Gert Helgesson
Journal:  Lancet Oncol       Date:  2006-03       Impact factor: 41.316

6.  Ethics and research with deceased patients.

Authors:  Mark R Wicclair
Journal:  Camb Q Healthc Ethics       Date:  2008       Impact factor: 1.284

7.  Offering individual genetic research results: context matters.

Authors:  Laura M Beskow; Wylie Burke
Journal:  Sci Transl Med       Date:  2010-06-30       Impact factor: 17.956

8.  How anonymous is 'anonymous'? Some suggestions towards a coherent universal coding system for genetic samples.

Authors:  Harald Schmidt; Shawneequa Callier
Journal:  J Med Ethics       Date:  2012-02-16       Impact factor: 2.903

Review 9.  Brain death and the courts.

Authors:  Christopher M Burkle; Agnes M Schipper; Eelco F M Wijdicks
Journal:  Neurology       Date:  2011-03-01       Impact factor: 9.910

10.  On sharing quantitative trait GWAS results in an era of multiple-omics data and the limits of genomic privacy.

Authors:  Hae Kyung Im; Eric R Gamazon; Dan L Nicolae; Nancy J Cox
Journal:  Am J Hum Genet       Date:  2012-03-28       Impact factor: 11.025

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  3 in total

1.  Authorization of tissues from deceased patients for genetic research.

Authors:  Maureen Wilson-Genderson; K Laura Barker; Heather M Gardiner; Maghboeba Mosavel; Jeffrey Thomas; Laura A Siminoff
Journal:  Hum Genet       Date:  2017-12-04       Impact factor: 4.132

2.  Still Human: A Call for Increased Focus on Ethical Standards in Cadaver Research.

Authors:  Michelle C Bach
Journal:  HEC Forum       Date:  2016-12

3.  Ethical considerations for HIV cure-related research at the end of life.

Authors:  Karine Dubé; Sara Gianella; Susan Concha-Garcia; Susan J Little; Andy Kaytes; Jeff Taylor; Kushagra Mathur; Sogol Javadi; Anshula Nathan; Hursch Patel; Stuart Luter; Sean Philpott-Jones; Brandon Brown; Davey Smith
Journal:  BMC Med Ethics       Date:  2018-10-20       Impact factor: 2.652

  3 in total

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