Daihui Peng1, Feng Shi2, Ting Shen3, Ziwen Peng2, Chen Zhang3, Xiaohua Liu3, Meihui Qiu3, Jun Liu4, Kaida Jiang5, Yiru Fang6, Dinggang Shen7. 1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping South Road, Shanghai 200030, PR China; Department of Radiology and BRIC, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599-7513, USA. 2. Department of Radiology and BRIC, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599-7513, USA. 3. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping South Road, Shanghai 200030, PR China. 4. Department of Medical Imaging, the Fifth People׳s Hospital of Shanghai, Shanghai, PR China. 5. Huashan Hospital, Fudan University, Shanghai, PR China. 6. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping South Road, Shanghai 200030, PR China. Electronic address: yirufang@gmail.com. 7. Department of Radiology and BRIC, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599-7513, USA; Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea. Electronic address: dgshen@med.unc.edu.
Abstract
OBJECTIVE: The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD. METHODS: Resting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDD patients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDD patients were measured to reflect the regional roles in module network, and the impairment of FC was examined by network based statistic. RESULTS: Small-world property was not altered in MDD. However, MDD patients exhibited 5 atypically reorganized modules compared to the controls. A positive relationship was also found among MDD patients between the intra-module I and helplessness factor evaluated via the Hamilton Depression Scale. Specifically, eight regions exhibited the abnormal participant coefficient or module degree, e.g., left superior orbital frontal cortex and right amygdala. The decreased FC was identified among the sub-network of 24 brain regions, e.g., frontal cortex, supplementary motor area, amygdala, thalamus, and hippocampus. LIMITATION: The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC. CONCLUSIONS: The results revealed altered patterns of brain module network at the global level in MDD patients, which might contribute to the feelings of helplessness.
OBJECTIVE: The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD. METHODS: Resting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDDpatients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDDpatients were measured to reflect the regional roles in module network, and the impairment of FC was examined by network based statistic. RESULTS: Small-world property was not altered in MDD. However, MDDpatients exhibited 5 atypically reorganized modules compared to the controls. A positive relationship was also found among MDDpatients between the intra-module I and helplessness factor evaluated via the Hamilton Depression Scale. Specifically, eight regions exhibited the abnormal participant coefficient or module degree, e.g., left superior orbital frontal cortex and right amygdala. The decreased FC was identified among the sub-network of 24 brain regions, e.g., frontal cortex, supplementary motor area, amygdala, thalamus, and hippocampus. LIMITATION: The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC. CONCLUSIONS: The results revealed altered patterns of brain module network at the global level in MDDpatients, which might contribute to the feelings of helplessness.
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