Xueling Suo1, Du Lei1, Lei Li1, Wenbin Li1, Jing Dai1, Song Wang1, Manxi He1, Hongyan Zhu1, Graham J Kemp1, Qiyong Gong1. 1. From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Abstract
BACKGROUND: Brain connectome research based on graph theoretical analysis shows that small-world topological properties play an important role in the structural and functional alterations observed in patients with psychiatric disorders. However, the reported global topological alterations in small-world properties are controversial, are not consistently conceptualized according to agreed-upon criteria, and are not critically examined for consistent alterations in patients with each major psychiatric disorder. METHODS: Based on a comprehensive PubMed search, we systematically reviewed studies using noninvasive neuroimaging data and graph theoretical approaches for 6 major psychiatric disorders: schizophrenia, major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Here, we describe the main patterns of altered small-world properties and then systematically review the evidence for these alterations in the structural and functional connectome in patients with these disorders. RESULTS: We selected 40 studies of schizophrenia, 33 studies of MDD, 5 studies of ADHD, 5 studies of BD, 7 studies of OCD and 5 studies of PTSD. The following 4 patterns of altered small-world properties are defined from the perspectives of segregation and integration: "regularization," "randomization," "stronger small-worldization" and "weaker small-worldization." Although more differences than similarities are noted in patients with these disorders, a prominent trend is the structural regularization versus functional randomization in patients with schizophrenia. LIMITATIONS: Differences in demographic and clinical characteristics, preprocessing steps and analytical methods can produce contradictory results, increasing the difficulty of integrating results across different studies. CONCLUSION: Four psychoradiological patterns of altered small-world properties are proposed. The analysis of altered small-world properties may provide novel insights into the pathophysiological mechanisms underlying psychiatric disorders from a connectomic perspective. In future connectome studies, the global network measures of both segregation and integration should be calculated to fully evaluate altered small-world properties in patients with a particular disease.
BACKGROUND: Brain connectome research based on graph theoretical analysis shows that small-world topological properties play an important role in the structural and functional alterations observed in patients with psychiatric disorders. However, the reported global topological alterations in small-world properties are controversial, are not consistently conceptualized according to agreed-upon criteria, and are not critically examined for consistent alterations in patients with each major psychiatric disorder. METHODS: Based on a comprehensive PubMed search, we systematically reviewed studies using noninvasive neuroimaging data and graph theoretical approaches for 6 major psychiatric disorders: schizophrenia, major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Here, we describe the main patterns of altered small-world properties and then systematically review the evidence for these alterations in the structural and functional connectome in patients with these disorders. RESULTS: We selected 40 studies of schizophrenia, 33 studies of MDD, 5 studies of ADHD, 5 studies of BD, 7 studies of OCD and 5 studies of PTSD. The following 4 patterns of altered small-world properties are defined from the perspectives of segregation and integration: "regularization," "randomization," "stronger small-worldization" and "weaker small-worldization." Although more differences than similarities are noted in patients with these disorders, a prominent trend is the structural regularization versus functional randomization in patients with schizophrenia. LIMITATIONS: Differences in demographic and clinical characteristics, preprocessing steps and analytical methods can produce contradictory results, increasing the difficulty of integrating results across different studies. CONCLUSION: Four psychoradiological patterns of altered small-world properties are proposed. The analysis of altered small-world properties may provide novel insights into the pathophysiological mechanisms underlying psychiatric disorders from a connectomic perspective. In future connectome studies, the global network measures of both segregation and integration should be calculated to fully evaluate altered small-world properties in patients with a particular disease.
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