| Literature DB >> 9466512 |
J I Maiztegui1, K T McKee, J G Barrera Oro, L H Harrison, P H Gibbs, M R Feuillade, D A Enria, A M Briggiler, S C Levis, A M Ambrosio, N A Halsey, C J Peters.
Abstract
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.Entities:
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Year: 1998 PMID： 9466512 DOI： 10.1086/514211
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226