Literature DB >> 25028870

New pipelines for novel allosteric GPCR modulators.

R Scott Prosser1.   

Abstract

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Year:  2014        PMID： 25028870      PMCID： PMC4104044          DOI： 10.1016/j.bpj.2014.06.016

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


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  7 in total

Review 1.  Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.

Authors:  Christa E Müller; Anke C Schiedel; Younis Baqi
Journal:  Pharmacol Ther       Date:  2012-06-19       Impact factor: 12.310

Review 2.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

Review 3.  Emerging paradigms in GPCR allostery: implications for drug discovery.

Authors:  Denise Wootten; Arthur Christopoulos; Patrick M Sexton
Journal:  Nat Rev Drug Discov       Date:  2013-08       Impact factor: 84.694

4.  Differences in allosteric communication pipelines in the inactive and active states of a GPCR.

Authors:  Supriyo Bhattacharya; Nagarajan Vaidehi
Journal:  Biophys J       Date:  2014-07-15       Impact factor: 4.033

5.  Activation mechanism of the β2-adrenergic receptor.

Authors:  Ron O Dror; Daniel H Arlow; Paul Maragakis; Thomas J Mildorf; Albert C Pan; Huafeng Xu; David W Borhani; David E Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-26       Impact factor: 11.205

6.  Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations.

Authors:  Ron O Dror; Daniel H Arlow; David W Borhani; Morten Ø Jensen; Stefano Piana; David E Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-03       Impact factor: 11.205

7.  Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics.

Authors:  Alessandro Pandini; Arianna Fornili; Franca Fraternali; Jens Kleinjung
Journal:  FASEB J       Date:  2011-11-09       Impact factor: 5.191
  7 in total
  1 in total

1.  Synergistic regulation mechanism of iperoxo and LY2119620 for muscarinic acetylcholine M2 receptor.

Authors:  Quan Li; Hai-Feng Chen
Journal:  RSC Adv       Date:  2018-04-09       Impact factor: 4.036
  1 in total

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