Literature DB >> 25012120

Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats.

Linlin Yin1, Yongyan Chen2, Zhao Qu3, Li Zhang4, Qi Wang3, Qi Zhang2, Lin Li5.   

Abstract

In the present study, we investigated the therapeutic benefit of cornel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20days and reduced disease severity, incidence, disease onset and ongoing paralysis. Histopathological staining showed that CIG could reduce T cell entry to the central nervous system and microglia activation, increased brain-derived neurotrophic factor (BDNF) expression and mature oligodendrocytes, and decreased oligodendrocyte progenitor cells (OPCs). Also, CIG treatment inhibited brain JAK/STAT1/3 and reduced proinflammatory cytokines. CIG might be a novel potential therapeutic agent for multiple sclerosis (MS).
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cornel iridoid glycoside; Experimental autoimmune encephalomyelitis; JAK/STAT signaling; Multiple sclerosis; Neuroinflammation

Mesh：

Substances：

Year:  2014        PMID： 25012120     DOI： 10.1016/j.jneuroim.2014.06.022

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

Review 1.  Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases.

Authors:  Yudong Liu; Sara A Gibson; Etty N Benveniste; Hongwei Qin
Journal:  Crit Rev Immunol       Date:  2015       Impact factor: 2.214

2.  Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury.

Authors:  Shuyong Wei; Jie Tong; Qiang Xue; Yang Liu; Xiaoyu Xu
Journal:  Mol Cell Biochem       Date:  2016-11-14       Impact factor: 3.396

3.  Cornel iridoid glycoside exerts a neuroprotective effect on neuroinflammation in rats with brain injury by inhibiting NF-κB and STAT3.

Authors:  Haitao Xiao; Yun Chen; Tingting Zheng; Jiao Peng; Tao Pei; Yu Shi; Li Liu; Keke Chen
Journal:  3 Biotech       Date:  2019-05-02       Impact factor: 2.406

4.  Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism.

Authors:  Sheikh Fayaz Ahmad; Khairy M A Zoheir; Mushtaq Ahmad Ansari; Ahmed Nadeem; Saleh A Bakheet; Laila Yousef Al-Ayadhi; Mohammad Zeed Alzahrani; Othman A Al-Shabanah; Mohammed M Al-Harbi; Sabry M Attia
Journal:  Mol Neurobiol       Date:  2016-06-25       Impact factor: 5.590

5.  Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system.

Authors:  Rongbo Zhang; Jin Liu; Bin Xu; You Wu; Shunli Liang; Qiang Yuan
Journal:  J Zhejiang Univ Sci B       Date:  2021-05-15       Impact factor: 3.066

Review 6.  Translational utility of experimental autoimmune encephalomyelitis: recent developments.

Authors:  Andre Ortlieb Guerreiro-Cacais; Hannes Laaksonen; Sevasti Flytzani; Marie N'diaye; Tomas Olsson; Maja Jagodic
Journal:  J Inflamm Res       Date:  2015-11-13

Review 7.  Corni Fructus: a review of chemical constituents and pharmacological activities.

Authors:  Yu Dong; Zhe-Ling Feng; Hu-Biao Chen; Fu-Sheng Wang; Jia-Hong Lu
Journal:  Chin Med       Date:  2018-06-25       Impact factor: 5.455

Review 8.  Cornus mas and Cornus Officinalis-Analogies and Differences of Two Medicinal Plants Traditionally Used.

Authors:  Monika E Czerwińska; Matthias F Melzig
Journal:  Front Pharmacol       Date:  2018-08-28       Impact factor: 5.810

Review 9.  Progress in the Application of Drugs for the Treatment of Multiple Sclerosis.

Authors:  Weipeng Wei; Denglei Ma; Lin Li; Lan Zhang
Journal:  Front Pharmacol       Date:  2021-07-13       Impact factor: 5.810
  9 in total

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