Literature DB >> 24990946

Cellular and physiological roles for phospholipase D1 in cancer.

Yi Zhang1, Michael A Frohman2.   

Abstract

Phospholipase D enzymes have long been proposed to play multiple cell biological roles in cancer. With the generation of phospholipase D1 (PLD1)-deficient mice and the development of small molecule PLD-specific inhibitors, in vivo roles for PLD1 in cancer are now being defined, both in the tumor cells and in the tumor environment. We review here tools now used to explore in vivo roles for PLD1 in cancer and summarize recent findings regarding functions in angiogenesis and metastasis.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Angiogenesis; Animal Model; Cell Signaling; Metastasis; Phospholipase D

Mesh：

Substances：

Year:  2014        PMID： 24990946      PMCID： PMC4132764          DOI： 10.1074/jbc.R114.576876

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  104 in total

1.  A role for phospholipase D in GLUT4 glucose transporter translocation.

Authors:  M Emoto; J K Klarlund; S B Waters; V Hu; J M Buxton; A Chawla; M P Czech
Journal:  J Biol Chem       Date:  2000-03-10       Impact factor: 5.157

2.  Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.

Authors:  Maria D Cao; Mailin Döpkens; Balaji Krishnamachary; Farhad Vesuna; Mayur M Gadiya; Per E Lønning; Zaver M Bhujwalla; Ingrid S Gribbestad; Kristine Glunde
Journal:  NMR Biomed       Date:  2012-01-26       Impact factor: 4.044

3.  Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells.

Authors:  Dong Woo Kang; Mi Hee Park; Young Jun Lee; Hyung Sik Kim; Craig W Lindsley; H Alex Brown; Do Sik Min
Journal:  Int J Cancer       Date:  2011-02-15       Impact factor: 7.396

4.  The phospholipase D1 pathway modulates macroautophagy.

Authors:  Claudia Dall'Armi; Andrés Hurtado-Lorenzo; Huasong Tian; Etienne Morel; Akiko Nezu; Robin B Chan; W Haung Yu; Kimberly S Robinson; Oladapo Yeku; Scott A Small; Karen Duff; Michael A Frohman; Markus R Wenk; Akitsugu Yamamoto; Gilbert Di Paolo
Journal:  Nat Commun       Date:  2010       Impact factor: 14.919

5.  Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.

Authors:  Yasunori Kanaho; Takanobu Sato; Tsunaki Hongu; Yuji Funakoshi
Journal:  Adv Biol Regul       Date:  2012-09-28

6.  Ca2+-mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation.

Authors:  S B Bocckino; P B Wilson; J H Exton
Journal:  FEBS Lett       Date:  1987-12-10       Impact factor: 4.124

7.  Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1.

Authors:  Ping Huang; Yelena M Altshuller; June Chunqiu Hou; Jeffrey E Pessin; Michael A Frohman
Journal:  Mol Biol Cell       Date:  2005-03-16       Impact factor: 4.138

8.  CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation.

Authors:  A Pupovac; L Stokes; R Sluyter
Journal:  Purinergic Signal       Date:  2013-06-21       Impact factor: 3.765

9.  Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.

Authors:  W C Colley; T C Sung; R Roll; J Jenco; S M Hammond; Y Altshuller; D Bar-Sagi; A J Morris; M A Frohman
Journal:  Curr Biol       Date:  1997-03-01       Impact factor: 10.834

10.  The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

Authors:  Adam Mor; Gabriele Campi; Guangwei Du; Yang Zheng; David A Foster; Michael L Dustin; Mark R Philips
Journal:  Nat Cell Biol       Date:  2007-05-07       Impact factor: 28.824
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  20 in total

1.  Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer.

Authors:  Benjamin Purow
Journal:  Clin Cancer Res       Date:  2015-09-29       Impact factor: 12.531

Review 2.  The phospholipase D superfamily as therapeutic targets.

Authors:  Michael A Frohman
Journal:  Trends Pharmacol Sci       Date:  2015-02-03       Impact factor: 14.819

3.  A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis.

Authors:  Timothy W Bumpus; Jeremy M Baskin
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-10       Impact factor: 15.336

4.  BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor-Mediated Calcium Signaling.

Authors:  Sarah C Pyfrom; Chaz C Quinn; Hannah K Dorando; Hong Luo; Jacqueline E Payton
Journal:  J Immunol       Date:  2020-06-22       Impact factor: 5.422

5.  A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.

Authors:  Dongjun Liang; Kane Wu; Reika Tei; Timothy W Bumpus; Johnny Ye; Jeremy M Baskin
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-16       Impact factor: 11.205

6.  Thematic minireview series on phospholipase D and cancer.

Authors:  Julian Gomez-Cambronero; George M Carman
Journal:  J Biol Chem       Date:  2014-07-02       Impact factor: 5.157

Review 7.  Proliferative and metastatic roles for Phospholipase D in mouse models of cancer.

Authors:  Eric Roth; Michael A Frohman
Journal:  Adv Biol Regul       Date:  2017-11-14

Review 8.  Phospholipase D and Choline Metabolism.

Authors:  Fredrick O Onono; Andrew J Morris
Journal:  Handb Exp Pharmacol       Date:  2020

Review 9.  Mammalian phospholipase D: Function, and therapeutics.

Authors:  M I McDermott; Y Wang; M J O Wakelam; V A Bankaitis
Journal:  Prog Lipid Res       Date:  2019-12-09       Impact factor: 16.195

10.  MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma.

Authors:  Jiwei Zhang; Zehua Bian; Jialiang Zhou; Mingxu Song; Zhihui Liu; Yuyang Feng; Li Zhe; Binbin Zhang; Yuan Yin; Zhaohui Huang
Journal:  Protein Cell       Date:  2015-08-07       Impact factor: 14.870
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