| Literature DB >> 23062771 |
Yasunori Kanaho1, Takanobu Sato, Tsunaki Hongu, Yuji Funakoshi.
Abstract
In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 is involved in these fMLP-induced neutrophil functions. The results obtained in this study provide evidence that cPKC plays an important role in fMLP-induced superoxide generation. On the other hand, Ca(2+)-dependent signaling pathway and cPKC seem to be involved in degranulation.Entities:
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Year: 2012 PMID： 23062771 DOI： 10.1016/j.jbior.2012.09.001
Source DB: PubMed Journal: Adv Biol Regul ISSN： 2212-4926