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Literature DB >> 24981760

Subcutaneous drug delivery and the role of the lymphatics.

Danielle N McLennan¹, Christopher J H Porter², Susan A Charman³.

Abstract

Subcutaneous injections are widely utilised as a delivery route for compounds with limited oral bioavailability or as a means to modify or extend the release profile. In this review, factors affecting absorption from the subcutaneous space are discussed with particular emphasis on differential drug absorption into either the underlying blood or lymphatic capillaries. Formulation and targeted delivery approaches, which utilise the subcutaneous administration route, are reviewed with reference to associated technologies and future challenges.:

Year: 2005 PMID： 24981760 DOI： 10.1016/j.ddtec.2005.05.006

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

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Cited

51 in total

Review 1. Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations.

Authors: Wassana Wijagkanalan; Shigeru Kawakami; Mitsuru Hashida
Journal: Pharm Res Date: 2010-12-23 Impact factor: 4.200

2. Drug elimination kinetics following subconjunctival injection using dynamic contrast-enhanced magnetic resonance imaging.

Authors: Stephanie H Kim; Karl G Csaky; Nam Sun Wang; Robert J Lutz
Journal: Pharm Res Date: 2007-08-03 Impact factor: 4.200

3. The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.

Authors: Danielle N McLennan; Christopher J H Porter; Glenn A Edwards; Anne C Heatherington; Steven W Martin; Susan A Charman
Journal: Pharm Res Date: 2006-08-09 Impact factor: 4.200

4. Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants.

Authors: Melissa C Hanson; Monica P Crespo; Wuhbet Abraham; Kelly D Moynihan; Gregory L Szeto; Stephanie H Chen; Mariane B Melo; Stefanie Mueller; Darrell J Irvine
Journal: J Clin Invest Date: 2015-05-04 Impact factor: 14.808

5. Subcutaneous absorption of monoclonal antibodies: role of dose, site of injection, and injection volume on rituximab pharmacokinetics in rats.

Authors: Leonid Kagan; Michael R Turner; Sathy V Balu-Iyer; Donald E Mager
Journal: Pharm Res Date: 2011-09-02 Impact factor: 4.200

10. PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

Authors: Lisa M Kaminskas; David B Ascher; Victoria M McLeod; Marco J Herold; Caroline P Le; Erica K Sloan; Christopher J H Porter
Journal: J Control Release Date: 2013-03-15 Impact factor: 9.776

Subcutaneous drug delivery and the role of the lymphatics.

Review 1. Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations.

2. Drug elimination kinetics following subconjunctival injection using dynamic contrast-enhanced magnetic resonance imaging.

3. The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.

4. Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants.

5. Subcutaneous absorption of monoclonal antibodies: role of dose, site of injection, and injection volume on rituximab pharmacokinetics in rats.

6. Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs.

Review 7. Engineering New Approaches to Cancer Vaccines.

8. Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Model Development.

Review 9. Liposomal adjuvant development for leishmaniasis vaccines.

10. PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.