PURPOSE: To study retinal function in asymptomatic Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema. METHODS: Thirty-six consecutive Type 1 and Type 2 diabetic patients with nonproliferative diabetic retinopathy and no diabetic macular edema and 28 healthy controls underwent a complete ophthalmologic examination, including spectral domain optical coherence tomography and microperimetry. RESULTS: Seventy-one eyes (17 patients with Type 1 and 19 with Type 2 diabetes) were tested, and data from 36 (17 Type 1 and 19 Type 2) eyes were analyzed. Mean best-corrected visual acuity was 0.00 ± 0.01 logMAR and 0.00 ± 0.02 logMAR for Type 1 and Type 2 diabetic patients, respectively (P = 0.075). Mean central foveal thickness was 234.5 ± 13.7 μm and 256.3 ± 12.7 μm for Type 1 and Type 2 diabetic patients, respectively (P = 0.04); the central foveal thickness was statistically different compared with the control groups (P = 0.04 and P = 0.01, respectively). Mean retinal sensitivity was 18.9 ± 0.5 dB and 17.7 ± 0.4 dB for Type 1 and Type 2 diabetic patients, respectively; it was statistically different compared with control groups (P < 0.0001 and P < 0.0001, respectively). CONCLUSION: We demonstrated a significantly reduced sensitivity in both nonproliferative diabetic retinopathy groups without diabetic macular edema compared with healthy controls; this reduction was greater in Type 2 diabetic patients. Central foveal thickness was increased in all diabetic patients compared with healthy controls, despite the absence of diabetic macular edema.
PURPOSE: To study retinal function in asymptomatic Type 1 and Type 2 diabeticpatients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema. METHODS: Thirty-six consecutive Type 1 and Type 2 diabeticpatients with nonproliferative diabetic retinopathy and no diabetic macular edema and 28 healthy controls underwent a complete ophthalmologic examination, including spectral domain optical coherence tomography and microperimetry. RESULTS: Seventy-one eyes (17 patients with Type 1 and 19 with Type 2 diabetes) were tested, and data from 36 (17 Type 1 and 19 Type 2) eyes were analyzed. Mean best-corrected visual acuity was 0.00 ± 0.01 logMAR and 0.00 ± 0.02 logMAR for Type 1 and Type 2 diabeticpatients, respectively (P = 0.075). Mean central foveal thickness was 234.5 ± 13.7 μm and 256.3 ± 12.7 μm for Type 1 and Type 2 diabeticpatients, respectively (P = 0.04); the central foveal thickness was statistically different compared with the control groups (P = 0.04 and P = 0.01, respectively). Mean retinal sensitivity was 18.9 ± 0.5 dB and 17.7 ± 0.4 dB for Type 1 and Type 2 diabeticpatients, respectively; it was statistically different compared with control groups (P < 0.0001 and P < 0.0001, respectively). CONCLUSION: We demonstrated a significantly reduced sensitivity in both nonproliferative diabetic retinopathy groups without diabetic macular edema compared with healthy controls; this reduction was greater in Type 2 diabeticpatients. Central foveal thickness was increased in all diabeticpatients compared with healthy controls, despite the absence of diabetic macular edema.
Authors: P Carpineto; L Toto; R Aloia; V Ciciarelli; E Borrelli; E Vitacolonna; M Di Nicola; L Di Antonio; R Mastropasqua Journal: Eye (Lond) Date: 2016-02-12 Impact factor: 3.775
Authors: G Montesano; A Gervasoni; P Ferri; D Allegrini; L Migliavacca; S De Cillà; L Rossetti Journal: Eye (Lond) Date: 2017-03-03 Impact factor: 3.775
Authors: Rodolfo Mastropasqua; Lisa Toto; Enrico Borrelli; Luca Di Antonio; Chiara De Nicola; Alessandra Mastrocola; Marta Di Nicola; Paolo Carpineto Journal: PLoS One Date: 2015-12-31 Impact factor: 3.240
Authors: Zhongjie Fu; Chuck T Chen; Gael Cagnone; Emilie Heckel; Ye Sun; Bertan Cakir; Yohei Tomita; Shuo Huang; Qian Li; William Britton; Steve S Cho; Timothy S Kern; Ann Hellström; Jean-Sébastien Joyal; Lois Eh Smith Journal: EMBO Mol Med Date: 2019-09-05 Impact factor: 14.260