Elvira Orduna-Hospital1,2, Judit Otero-Rodríguez2, Lorena Perdices1, Ana Sánchez-Cano1,2, Ana Boned-Murillo1,3, Javier Acha1,4, Isabel Pinilla1,3. 1. Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain. 2. Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain. 3. Department of Ophthalmology, Lozano Blesa University Hospital, 50009 Zaragoza, Spain. 4. Department of Endocrinology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Abstract
BACKGROUND: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). METHODS: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. RESULTS: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5° nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. CONCLUSION: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.
BACKGROUND: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellituspatients (DM1) without diabetic retinopathy (DR). METHODS: Fifty-one DM1patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. RESULTS: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1patients. Only a mild negative correlation was observed between retinal sensitivity in the 5° nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. CONCLUSION: Aging and disease evolution in DM1patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.
Authors: P Carpineto; L Toto; R Aloia; V Ciciarelli; E Borrelli; E Vitacolonna; M Di Nicola; L Di Antonio; R Mastropasqua Journal: Eye (Lond) Date: 2016-02-12 Impact factor: 3.775
Authors: A A Dosso; E R Bonvin; Y Morel; A Golay; J P Assal; P M Leuenberger Journal: Graefes Arch Clin Exp Ophthalmol Date: 1996-05 Impact factor: 3.117
Authors: Christopher Kai-shun Leung; Robert N Weinreb; Zhi Wei Li; Shu Liu; James D Lindsey; Nathan Choi; Lan Liu; Carol Yim-lui Cheung; Cong Ye; Kunliang Qiu; Li Jia Chen; Wing Ho Yung; Jonathan G Crowston; Mingliang Pu; Kwok Fai So; Chi Pui Pang; Dennis Shun Chiu Lam Journal: Invest Ophthalmol Vis Sci Date: 2011-03-01 Impact factor: 4.799
Authors: I Pinilla; A Sanchez-Cano; A Ferreras; J Acha; D Pérez-García; J Ibañez-Alperte; E Abecia Journal: Exp Clin Endocrinol Diabetes Date: 2016-09-22 Impact factor: 2.949
Authors: Amaya Pérez Del Palomar; José Cegoñino; Alberto Montolío; Elvira Orduna; Elisa Vilades; Berta Sebastián; Luis E Pablo; Elena Garcia-Martin Journal: PLoS One Date: 2019-05-06 Impact factor: 3.240
Authors: Emily S Levine; Eric M Moult; Eugenia Custo Greig; Yi Zhao; Varsha Pramil; Isaac Gendelman; Agha Y Alibhai; Caroline R Baumal; Andre J Witkin; Jay S Duker; James G Fujimoto; Nadia K Waheed Journal: Retina Date: 2022-02-01 Impact factor: 4.256