PURPOSE: Our aim was to compare optic disc parameters, retinal nerve fiber (RNFL) and macular ganglion cell layers between children and adolescents with diabetes mellitus (type 1) and healthy controls. METHODS: Sixty-three eyes of 63 pediatric diabetic patients without diabetic retinopathy and 44 eyes of 44 healthy controls were included in this cross-sectional and comparative study. Diabetic and control groups were similar in the aspect of age, gender and refractive error. Measurements of optic disc parameters (i.e., rim area, disc area, cup-to-disc ratio, cup volume), thickness of RNFL and macular ganglion cell-inner plexiform layers (GCL + IPL) were taken with the spectral domain optical coherence tomography. RESULTS: There were not statistically significant differences between the diabetic patients and healthy controls in terms of intraocular pressure (p = 0.14), retinal nerve fiber layer thickness (p = 0.61), rim area (p = 0.92), disc area (p = 0.10), vertical cup-to-disc ratio (p = 0.16), cup volume (p = 0.13), and average macular GCL + IPL thickness (p = 0.43). On the other hand, binocular RNFL thickness symmetry percentage was statistically significantly different in the diabetic and control groups (p = 0.01). CONCLUSION: Diabetic children and adolescents without diabetic retinopathy have more binocular RNFL thickness asymmetry compared to healthy controls.
PURPOSE: Our aim was to compare optic disc parameters, retinal nerve fiber (RNFL) and macular ganglion cell layers between children and adolescents with diabetes mellitus (type 1) and healthy controls. METHODS: Sixty-three eyes of 63 pediatric diabeticpatients without diabetic retinopathy and 44 eyes of 44 healthy controls were included in this cross-sectional and comparative study. Diabetic and control groups were similar in the aspect of age, gender and refractive error. Measurements of optic disc parameters (i.e., rim area, disc area, cup-to-disc ratio, cup volume), thickness of RNFL and macular ganglion cell-inner plexiform layers (GCL + IPL) were taken with the spectral domain optical coherence tomography. RESULTS: There were not statistically significant differences between the diabeticpatients and healthy controls in terms of intraocular pressure (p = 0.14), retinal nerve fiber layer thickness (p = 0.61), rim area (p = 0.92), disc area (p = 0.10), vertical cup-to-disc ratio (p = 0.16), cup volume (p = 0.13), and average macular GCL + IPL thickness (p = 0.43). On the other hand, binocular RNFL thickness symmetry percentage was statistically significantly different in the diabetic and control groups (p = 0.01). CONCLUSION:Diabeticchildren and adolescents without diabetic retinopathy have more binocular RNFL thickness asymmetry compared to healthy controls.
Authors: Constantine D Georgakopoulos; Maria I Eliopoulou; Artemis M Exarchou; Vasileios Tzimis; Nikolaos M Pharmakakis; Bessie E Spiliotis Journal: J Pediatr Ophthalmol Strabismus Date: 2010-04-22 Impact factor: 1.402
Authors: Hille W van Dijk; Frank D Verbraak; Marilette Stehouwer; Pauline H B Kok; Mona K Garvin; Milan Sonka; J Hans DeVries; Reinier O Schlingemann; Michael D Abràmoff Journal: Vision Res Date: 2010-08-27 Impact factor: 1.886
Authors: Hille W van Dijk; Frank D Verbraak; Pauline H B Kok; Mona K Garvin; Milan Sonka; Kyungmoo Lee; J Hans Devries; Robert P J Michels; Mirjam E J van Velthoven; Reinier O Schlingemann; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2010-02-03 Impact factor: 4.799
Authors: Hille W van Dijk; Pauline H B Kok; Mona Garvin; Milan Sonka; J Hans Devries; Robert P J Michels; Mirjam E J van Velthoven; Reinier O Schlingemann; Frank D Verbraak; Michael D Abràmoff Journal: Invest Ophthalmol Vis Sci Date: 2009-01-17 Impact factor: 4.799
Authors: Ziqi Tang; Ming Yan Chan; Wai Yin Leung; Ho Yeung Wong; Ching Man Ng; Victor T T Chan; Raymond Wong; Jerry Lok; Simon Szeto; Jason C K Chan; Clement C Tham; Tien Y Wong; Carol Y Cheung Journal: Eye (Lond) Date: 2020-06-24 Impact factor: 3.775