Literature DB >> 24976942

Synthesis and Antimicrobial Activities of His(2-aryl)-Arg and Trp-His(2-aryl) Classes of Dipeptidomimetics.

Amit Mahindra1, Krishna K Sharma1, Dinesh Rathore1, Shabana I Khan2, Melissa R Jacob2, Rahul Jain1.   

Abstract

In this communication, we report the design, synthesis and in vitro antimicrobial activity of ultra short peptidomimetics. Besides producing promising antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), the dipeptidomimetics exhibited high antifungal activity against C. neoformans with IC50 values in the range of 0.16-19 μg/mL. The most potent analogs exhibited 4-fold higher activity than the currently used drug amphotericin B, with no apparent cytotoxicity in a panel of mammalian cell lines.

Entities:  

Year:  2014        PMID： 24976942      PMCID： PMC4066839          DOI： 10.1039/C4MD00041B

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  26 in total

1.  The pharmacophore of short cationic antibacterial peptides.

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Review 2.  Peptide antimicrobial agents.

Authors:  Håvard Jenssen; Pamela Hamill; Robert E W Hancock
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Review 3.  The future of peptide-based drugs.

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4.  In vitro antibacterial properties of pexiganan, an analog of magainin.

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Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

Review 5.  Fungal infections: a growing threat.

Authors:  D M Dixon; M M McNeil; M L Cohen; B G Gellin; J R La Montagne
Journal:  Public Health Rep       Date:  1996 May-Jun       Impact factor: 2.792

Review 6.  Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.

Authors:  Benjamin J Park; Kathleen A Wannemuehler; Barbara J Marston; Nelesh Govender; Peter G Pappas; Tom M Chiller
Journal:  AIDS       Date:  2009-02-20       Impact factor: 4.177

7.  Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee.

Authors:  Raif S Geha; Luigi D Notarangelo; Jean-Laurent Casanova; Helen Chapel; Mary Ellen Conley; Alain Fischer; Lennart Hammarström; Shigeaki Nonoyama; Hans D Ochs; Jennifer M Puck; Chaim Roifman; Reinhard Seger; Josiah Wedgwood
Journal:  J Allergy Clin Immunol       Date:  2007-10       Impact factor: 10.793

Review 8.  Current challenges in the management of invasive fungal infections.

Authors:  Chih-Cheng Lai; Che-Kim Tan; Yu-Tsung Huang; Pei-Lan Shao; Po-Ren Hsueh
Journal:  J Infect Chemother       Date:  2008-04-30       Impact factor: 2.211

9.  Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.

Authors:  Manuel Cuenca-Estrella; Alicia Gomez-Lopez; Emilia Mellado; Maria J Buitrago; Araceli Monzon; Juan Luis Rodriguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191

10.  High ongoing burden of cryptococcal disease in Africa despite antiretroviral roll out.

Authors:  Joseph N Jarvis; Andrew Boulle; Angela Loyse; Tihana Bicanic; Kevin Rebe; Anthony Williams; Thomas S Harrison; Graeme Meintjes
Journal:  AIDS       Date:  2009-06-01       Impact factor: 4.177
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  2 in total

1.  Synthesis, stability and mechanistic studies of potent anticryptococcal hexapeptides.

Authors:  Kitika Shenmar; Krishna K Sharma; Nishima Wangoo; Indresh K Maurya; Vinod Kumar; Shabana I Khan; Melissa R Jacob; Kulbhushan Tikoo; Rahul Jain
Journal:  Eur J Med Chem       Date:  2017-03-24       Impact factor: 6.514

2.  Synthesis and Biological Evaluation of 8-Quinolinamines and Their Amino Acid Conjugates as Broad-Spectrum Anti-infectives.

Authors:  Meenakshi Jain; C V Ravi P Reddy; Moumita Halder; Savita Singh; Randheer Kumar; Sagar Gajbe Wasudeo; Prati Pal Singh; Shabana I Khan; Melissa R Jacob; Babu L Tekwani; Rahul Jain
Journal:  ACS Omega       Date:  2018-03-14
  2 in total

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