| Literature DB >> 12699374 |
Morten B Strøm1, Bengt Erik Haug, Merete L Skar, Wenche Stensen, Trine Stiberg, John S Svendsen.
Abstract
Cationic antibacterial peptides have been proclaimed as new drugs against multiresistant bacteria. Their limited success so far is partially due to the size of the peptides, which gives rise to unresolved issues regarding administration, bioavailability, metabolic stability, and immunogenicity. We have systematically investigated the minimum antibacterial motif of cationic antibacterial peptides regarding charge and lipophilicity/bulk and found that the pharmacophore was surprisingly small, opening the opportunity for development of short antibacterial peptides for systemic use.Mesh：
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Year: 2003 PMID： 12699374 DOI： 10.1021/jm0340039
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446