OBJECTIVE: Thyroid dysfunction may accelerate atherosclerosis. Aortic pulse wave velocity (PWV) is an early index of arterial stiffness and an important risk factor for cardiovascular disease and might therefore be linked to changes in thyroid activity. We investigated the relationship between thyroid function and carotid-femoral PWV, as an index of arterial stiffness. DESIGN: Cross-sectional cohort study. PATIENTS: Participants from the SardiNIA study. Those being treated for thyroid diseases were excluded, yielding a sample of 5875 aged 14-102. MEASUREMENTS: Clinical parameters, blood tests including serum TSH and serum FT4, and carotid-femoral PWV were measured. RESULTS: After adjusting for confounders, a direct and linear association between FT4 and PWV was shown (multiple regression analysis). The model containing age, mean blood pressure, body mass index, heart rate, FT4, hypertension, diabetes and dyslipidaemia accounted for 55% of the variation in PWV. CONCLUSIONS: Like several other known risk factors, serum FT4 levels are associated with carotid-femoral PWV, suggesting that high FT4 levels have a detrimental effect on aortic stiffness and may contribute to ageing process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy.
OBJECTIVE:Thyroid dysfunction may accelerate atherosclerosis. Aortic pulse wave velocity (PWV) is an early index of arterial stiffness and an important risk factor for cardiovascular disease and might therefore be linked to changes in thyroid activity. We investigated the relationship between thyroid function and carotid-femoral PWV, as an index of arterial stiffness. DESIGN: Cross-sectional cohort study. PATIENTS: Participants from the SardiNIA study. Those being treated for thyroid diseases were excluded, yielding a sample of 5875 aged 14-102. MEASUREMENTS: Clinical parameters, blood tests including serum TSH and serum FT4, and carotid-femoral PWV were measured. RESULTS: After adjusting for confounders, a direct and linear association between FT4 and PWV was shown (multiple regression analysis). The model containing age, mean blood pressure, body mass index, heart rate, FT4, hypertension, diabetes and dyslipidaemia accounted for 55% of the variation in PWV. CONCLUSIONS: Like several other known risk factors, serum FT4 levels are associated with carotid-femoral PWV, suggesting that high FT4 levels have a detrimental effect on aortic stiffness and may contribute to ageing process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy.
Authors: Alessandro P Delitala; Maristella Steri; Edoardo Fiorillo; Michele Marongiu; Edward G Lakatta; David Schlessinger; Francesco Cucca Journal: Cytokine Date: 2018-08-30 Impact factor: 3.861
Authors: A P Delitala; F Filigheddu; M Orrù; M AlGhatrif; M Steri; M G Pilia; A Scuteri; M Lobina; M G Piras; G Delitala; E G Lakatta; D Schlessinger; F Cucca Journal: Nutr Metab Cardiovasc Dis Date: 2015-10-21 Impact factor: 4.222
Authors: Ellen Boswijk; Karin J C Sanders; Evie P M Broeders; Marlies de Ligt; Guy H E J Vijgen; Bas Havekes; Alma M A Mingels; Roel Wierts; Wouter D van Marken Lichtenbelt; Patrick Schrauwen; Felix M Mottaghy; Joachim E Wildberger; Jan Bucerius Journal: Eur J Nucl Med Mol Imaging Date: 2019-03-11 Impact factor: 9.236
Authors: Alessandro P Delitala; Angelo Scuteri; Edoardo Fiorillo; Valeria Orrù; Edward G Lakatta; David Schlessinger; Francesco Cucca Journal: J Clin Med Date: 2021-01-22 Impact factor: 4.241