Alessandro P Delitala1, Maristella Steri2, Edoardo Fiorillo2, Michele Marongiu2, Edward G Lakatta3, David Schlessinger4, Francesco Cucca5. 1. Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Cagliari, Italy. Electronic address: aledelitala@tiscali.it. 2. Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Cagliari, Italy. 3. Laboratory Cardiovascular Sciences, Intramural Research Programme, National Insitute on Aging (NIA) - NIH, Baltimore, USA. 4. National Institute on Aging, NIH, DHHS, Baltimore, MD, USA. 5. Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Cagliari, Italy; Department of Biomedical Sciences, Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy.
Abstract
OBJECTIVE: Cytokines release by adipocytes could interact with TSH secretion. We evaluated the relationship between adipocytokines and TSH. We further tested for association of cytokines and thyroid autoimmunity. METHODS: We conducted a cross-sectional study in a community-based sample including 5385 individuals (2964 female) with TSH within the reference range. Subjects who reported taking thyroid medications or drugs that alter thyroid function were excluded. TSH, FT4, adiponectin, leptin, antibody against thyroperoxidase and against thyroglobulin were measured. Linear and logistic regression models were used to test for association. RESULTS: Females had higher adiponectin and leptin level and increased frequency of thyroid antibodies. In multiple regression analysis TSH was directly associated with leptin (β = 0.003, p = 0.001) and the presence of circulating antibody against thyroperoxidase (β = 0.315, p < 0.001), but negatively associated with age (β = -0.012, p < 0.001) and FT4 (β = -0.359, p < 0.001). Adiponectin, the presence of antibody against thyroglobulin and smoking habit were not associated with TSH levels (p = 0.223, p = 0.174 and p = 0.788, respectively). Logistic regression analysis revealed that higher adiponectin levels were associated with thyroid autoimmunity. CONCLUSIONS: Leptin is positively associated with TSH levels in euthyroid individuals, suggesting an effect of the adipokine on TSH secretion. Our results support the hypothesis that the leptin and pituitary-thyroid axis might interact in the context of energy homeostasis. The effect of adiponectin on thyroid autoimmunity will require more studies.
OBJECTIVE: Cytokines release by adipocytes could interact with TSH secretion. We evaluated the relationship between adipocytokines and TSH. We further tested for association of cytokines and thyroid autoimmunity. METHODS: We conducted a cross-sectional study in a community-based sample including 5385 individuals (2964 female) with TSH within the reference range. Subjects who reported taking thyroid medications or drugs that alter thyroid function were excluded. TSH, FT4, adiponectin, leptin, antibody against thyroperoxidase and against thyroglobulin were measured. Linear and logistic regression models were used to test for association. RESULTS: Females had higher adiponectin and leptin level and increased frequency of thyroid antibodies. In multiple regression analysis TSH was directly associated with leptin (β = 0.003, p = 0.001) and the presence of circulating antibody against thyroperoxidase (β = 0.315, p < 0.001), but negatively associated with age (β = -0.012, p < 0.001) and FT4 (β = -0.359, p < 0.001). Adiponectin, the presence of antibody against thyroglobulin and smoking habit were not associated with TSH levels (p = 0.223, p = 0.174 and p = 0.788, respectively). Logistic regression analysis revealed that higher adiponectin levels were associated with thyroid autoimmunity. CONCLUSIONS:Leptin is positively associated with TSH levels in euthyroid individuals, suggesting an effect of the adipokine on TSH secretion. Our results support the hypothesis that the leptin and pituitary-thyroid axis might interact in the context of energy homeostasis. The effect of adiponectin on thyroid autoimmunity will require more studies.
Authors: Alessandro P Delitala; Giuseppe Fanciulli; Giovanni M Pes; Margherita Maioli; Giuseppe Delitala Journal: Endocr Metab Immune Disord Drug Targets Date: 2017 Impact factor: 2.895
Authors: Angelo Scuteri; Christopher H Morrell; Marco Orrù; James B Strait; Kirill V Tarasov; Liana Anna Pina Ferreli; Francesco Loi; Maria Grazia Pilia; Alessandro Delitala; Harold Spurgeon; Samer S Najjar; Majd AlGhatrif; Edward G Lakatta Journal: Hypertension Date: 2014-09-15 Impact factor: 10.190
Authors: R V Lloyd; L Jin; I Tsumanuma; S Vidal; K Kovacs; E Horvath; B W Scheithauer; M E Couce; B Burguera Journal: Pituitary Date: 2001 Jan-Apr Impact factor: 4.107
Authors: Magdalena Zoledziewska; Carlo Sidore; Charleston W K Chiang; Serena Sanna; Antonella Mulas; Maristella Steri; Fabio Busonero; Joseph H Marcus; Michele Marongiu; Andrea Maschio; Diego Ortega Del Vecchyo; Matteo Floris; Antonella Meloni; Alessandro Delitala; Maria Pina Concas; Federico Murgia; Ginevra Biino; Simona Vaccargiu; Ramaiah Nagaraja; Kirk E Lohmueller; Nicholas J Timpson; Nicole Soranzo; Ioanna Tachmazidou; George Dedoussis; Eleftheria Zeggini; Sergio Uzzau; Chris Jones; Robert Lyons; Andrea Angius; Gonçalo R Abecasis; John Novembre; David Schlessinger; Francesco Cucca Journal: Nat Genet Date: 2015-09-14 Impact factor: 38.330
Authors: Alessandro P Delitala; Angelo Scuteri; Edoardo Fiorillo; Valeria Orrù; Edward G Lakatta; David Schlessinger; Francesco Cucca Journal: J Clin Med Date: 2021-01-22 Impact factor: 4.241